PDF(Pubmed)
Abstract：
Myocardial infarction (MI) can have significant physical and mental consequences. Depression is a prevalent psychiatric condition after MI which can reduce the quality of life and increase the mortality rates of patients. However, the connection between MI and depression has remained under-appreciated. This review examines the potential connection between depression and MI by overviewing the possible pathophysiologic mechanisms including dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, coagulation system dysfunction, inflammation, environmental factors, as well as, genetic factors. Furthermore, depression can be an adverse event of medications used for MI treatment including beta-blockers, statins, or anti-platelet agents. The need for early detection and management of depression in patients with MI is, therefore, crucial for improving their overall prognosis. Adherence to treatments and regular follow-up visits can ensure the best response to treatment.
摘要：
心肌梗死(MI)可具有显著的身体和精神后果。抑郁症是心肌梗死后普遍存在的一种精神疾病，可降低患者的生活质量，增加患者的死亡率。然而,心梗和抑郁症之间的联系仍然被低估。这篇综述通过概述可能的病理生理机制，包括下丘脑-垂体-肾上腺轴和自主神经系统的失调，探讨了抑郁症与MI之间的潜在联系。凝血系统功能障碍,炎症,环境因素,还有,遗传因素。此外，抑郁症可能是用于MI治疗的药物（包括β受体阻滞剂）的不良事件，他汀类药物，或抗血小板剂。需要及早发现和管理心肌梗死患者的抑郁症，因此,对改善其整体预后至关重要。坚持治疗和定期随访可以确保对治疗的最佳反应。
