Abstract：
Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Due to a lack of antiviral drugs and effective vaccines, several therapeutic and control strategies have been proposed. A systemic literature review was conducted according to PRISMA guidelines to select proper references to give an overview of DENV infection. Results indicate that understanding the virus characteristics and epidemiology are essential to gain the basic and clinical knowledge as well as dengue disseminated pattern and status. Different factors and mechanisms are thought to be involved in the presentation of DHF and DSS, including antibody-dependent enhancement, immune dysregulation, viral virulence, host genetic susceptibility, and preexisting dengue antibodies. This study suggests that dissecting pathogenesis and risk factors as well as developing different types of therapeutic and control strategies against DENV infection are urgently needed.
摘要：
登革热是由登革病毒（DENVs）感染引起的，临床表现包括登革热（DF），登革热出血热（DHF），或登革热休克综合征（DSS）。由于缺乏抗病毒药物和有效的疫苗，已经提出了几种治疗和控制策略。根据PRISMA指南进行了系统的文献综述，以选择适当的参考文献来概述DENV感染。结果表明，了解病毒特征和流行病学对于获得基础和临床知识以及登革热传播模式和状况至关重要。不同的因素和机制被认为涉及DHF和DSS的呈现，包括抗体依赖性增强，免疫失调，病毒毒力，宿主遗传易感性，和先前存在的登革热抗体。这项研究表明，迫切需要解剖发病机制和危险因素，以及开发针对DENV感染的不同类型的治疗和控制策略。
