OBJECTIVE: To evaluate the impact of a combined application of autologous platelet-rich plasma (PRP) and fat grafting as treatment for vulvar LS on patient quality of life.
METHODS: We reviewed the clinical charts of 72 patients affected by LS, who underwent regenerative surgery. The patients\' quality of life was assessed using: the Dermatology Life Quality Index (DLQI), the Skindex-29, the Female Sexual Function Index (FSFI) and the patient-administered - Clinical Scoring System (CSS).
RESULTS: After reconstructive surgery, all scores improved: Skindex-29 (-31.8 [IQR: 42.1, -21.8] points; p<0.001), FSFI (7.6 [IQR: 2.7, 14.7)] points; p<0.001), Patient-administered CSS (-24 [IQR: -30, -15] points; p<0.001), DLQI (-9 [IQR: -17, -7] points; p<0.001), Physician-administered CSS (-5 [IQR: -7, -5] points; p<0.001), and IGA (median ΔIGA: -4, IQR: -4, -3; p<0.001).
CONCLUSIONS: Combined treatment with PRP and fat grafting proved to be effective in improving the quality of life of patients with vulvar LS.
目的:评估联合应用自体富血小板血浆(PRP)和脂肪移植治疗外阴LS对患者生活质量的影响。
方法:我们回顾了72例LS患者的临床图表,接受再生手术的人。患者的生活质量评估使用:皮肤病学生活质量指数(DLQI),Skindex-29,女性性功能指数(FSFI)和患者管理的临床评分系统(CSS)。
结果:重建手术后,所有分数都提高了:Skindex-29(-31.8[IQR:42.1,-21.8]分;p<0.001),FSFI(7.6[IQR:2.7,14.7)]分;p<0.001),患者管理的CSS(-24[IQR:-30,-15]点;p<0.001),DLQI(-9[IQR:-17,-7]点;p<0.001),医师管理的CSS(-5[IQR:-7,-5]点;p<0.001),和IGA(中值ΔIGA:-4,IQR:-4,-3;p<0.001)。
结论:PRP和脂肪移植联合治疗被证明可有效改善外阴LS患者的生活质量。