Abstract：
BACKGROUND: Vulvar lichen sclerosus (LS) severely impairs patients\' quality of life.
OBJECTIVE: To evaluate the impact of a combined application of autologous platelet-rich plasma (PRP) and fat grafting as treatment for vulvar LS on patient quality of life.
METHODS: We reviewed the clinical charts of 72 patients affected by LS, who underwent regenerative surgery. The patients\' quality of life was assessed using: the Dermatology Life Quality Index (DLQI), the Skindex-29, the Female Sexual Function Index (FSFI) and the patient-administered - Clinical Scoring System (CSS).
RESULTS: After reconstructive surgery, all scores improved: Skindex-29 (-31.8 [IQR: 42.1, -21.8] points; p<0.001), FSFI (7.6 [IQR: 2.7, 14.7)] points; p<0.001), Patient-administered CSS (-24 [IQR: -30, -15] points; p<0.001), DLQI (-9 [IQR: -17, -7] points; p<0.001), Physician-administered CSS (-5 [IQR: -7, -5] points; p<0.001), and IGA (median ΔIGA: -4, IQR: -4, -3; p<0.001).
CONCLUSIONS: Combined treatment with PRP and fat grafting proved to be effective in improving the quality of life of patients with vulvar LS.
OBJECTIVE: To evaluate the impact of a combined application of autologous platelet-rich plasma (PRP) and fat grafting as treatment for vulvar LS on patient quality of life.
METHODS: We reviewed the clinical charts of 72 patients affected by LS, who underwent regenerative surgery. The patients\' quality of life was assessed using: the Dermatology Life Quality Index (DLQI), the Skindex-29, the Female Sexual Function Index (FSFI) and the patient-administered - Clinical Scoring System (CSS).
RESULTS: After reconstructive surgery, all scores improved: Skindex-29 (-31.8 [IQR: 42.1, -21.8] points; p<0.001), FSFI (7.6 [IQR: 2.7, 14.7)] points; p<0.001), Patient-administered CSS (-24 [IQR: -30, -15] points; p<0.001), DLQI (-9 [IQR: -17, -7] points; p<0.001), Physician-administered CSS (-5 [IQR: -7, -5] points; p<0.001), and IGA (median ΔIGA: -4, IQR: -4, -3; p<0.001).
CONCLUSIONS: Combined treatment with PRP and fat grafting proved to be effective in improving the quality of life of patients with vulvar LS.
摘要：
背景：硬化外阴苔藓(LS)严重损害患者的生活质量。
目的：评估联合应用自体富血小板血浆（PRP）和脂肪移植治疗外阴LS对患者生活质量的影响。
方法：我们回顾了72例LS患者的临床图表，接受再生手术的人。患者的生活质量评估使用：皮肤病学生活质量指数（DLQI），Skindex-29，女性性功能指数（FSFI）和患者管理的临床评分系统（CSS）。
结果：重建手术后，所有分数都提高了：Skindex-29（-31.8[IQR：42.1，-21.8]分；p<0.001），FSFI（7.6[IQR：2.7，14.7）]分；p<0.001），患者管理的CSS（-24[IQR：-30，-15]点；p<0.001），DLQI（-9[IQR：-17，-7]点；p<0.001），医师管理的CSS（-5[IQR：-7，-5]点；p<0.001），和IGA(中值ΔIGA:-4,IQR:-4,-3;p<0.001)。
结论：PRP和脂肪移植联合治疗被证明可有效改善外阴LS患者的生活质量。
目的：评估联合应用自体富血小板血浆（PRP）和脂肪移植治疗外阴LS对患者生活质量的影响。
方法：我们回顾了72例LS患者的临床图表，接受再生手术的人。患者的生活质量评估使用：皮肤病学生活质量指数（DLQI），Skindex-29，女性性功能指数（FSFI）和患者管理的临床评分系统（CSS）。
结果：重建手术后，所有分数都提高了：Skindex-29（-31.8[IQR：42.1，-21.8]分；p<0.001），FSFI（7.6[IQR：2.7，14.7）]分；p<0.001），患者管理的CSS（-24[IQR：-30，-15]点；p<0.001），DLQI（-9[IQR：-17，-7]点；p<0.001），医师管理的CSS（-5[IQR：-7，-5]点；p<0.001），和IGA(中值ΔIGA:-4,IQR:-4,-3;p<0.001)。
结论：PRP和脂肪移植联合治疗被证明可有效改善外阴LS患者的生活质量。
