Abstract：
OBJECTIVE: This study aimed to assess the association between dietary intake of preformed vitamin A (VA) and pro-VA carotenoids and serum retinol and carotenoid concentrations among 36-59-month-old children in a rural area in Burkina Faso.
METHODS: Two community-based cross-sectional studies were conducted in a rural area of Burkina Faso and included 115 children aged 36-59 months. Dietary intake of preformed VA and pro-VA was assessed directly by 24-h dietary recall. Serum retinol and carotenoid (α- and β-carotene, and β-cryptoxanthin) concentrations were measured. The associations between serum retinol and carotenoid concentrations and their respective dietary intake were assessed by multiple linear regression.
RESULTS: Geometric mean [95% CI] adjusted serum retinol concentration in children was 0.86 [0.81; 0.92] µmol/L. The prevalence of low adjusted serum retinol concentration (< 0.7 µmol/L) was 26.8%. Geometric mean [95% CI] serum carotenoid concentrations were: α-carotene (0.03 [0.02; 0.03] µmol/L), β-carotene (0.14 [0.12; 0.16] µmol/L), and β-cryptoxanthin (0.17 [0.15; 0.21] µmol/L). Dietary intakes of α- and β-carotene and adjusted serum retinol and α-carotene concentrations were significantly higher during the rainy season. In multiple linear regressions, no associations were found between dietary intakes of preformed VA and pro-VA carotenoids and serum retinol and carotenoid concentrations in children aged 36-59 months in Burkina Faso. There was no effect of season on the associations between preformed VA and pro-VA carotenoids intake and serum retinol and carotenoid concentrations.
CONCLUSIONS: This study shows that dietary intakes of preformed VA and pro-VA carotenoids based on 24-h dietary recall method cannot be used as proxy of serum retinol and carotenoid concentrations in this population.
BACKGROUND: The study was registered retrospectively (22 March 2018) as a clinical trial with the Pan African Clinical Trials Registry (Cochrane South Africa; PACTR201803002999356).
METHODS: Two community-based cross-sectional studies were conducted in a rural area of Burkina Faso and included 115 children aged 36-59 months. Dietary intake of preformed VA and pro-VA was assessed directly by 24-h dietary recall. Serum retinol and carotenoid (α- and β-carotene, and β-cryptoxanthin) concentrations were measured. The associations between serum retinol and carotenoid concentrations and their respective dietary intake were assessed by multiple linear regression.
RESULTS: Geometric mean [95% CI] adjusted serum retinol concentration in children was 0.86 [0.81; 0.92] µmol/L. The prevalence of low adjusted serum retinol concentration (< 0.7 µmol/L) was 26.8%. Geometric mean [95% CI] serum carotenoid concentrations were: α-carotene (0.03 [0.02; 0.03] µmol/L), β-carotene (0.14 [0.12; 0.16] µmol/L), and β-cryptoxanthin (0.17 [0.15; 0.21] µmol/L). Dietary intakes of α- and β-carotene and adjusted serum retinol and α-carotene concentrations were significantly higher during the rainy season. In multiple linear regressions, no associations were found between dietary intakes of preformed VA and pro-VA carotenoids and serum retinol and carotenoid concentrations in children aged 36-59 months in Burkina Faso. There was no effect of season on the associations between preformed VA and pro-VA carotenoids intake and serum retinol and carotenoid concentrations.
CONCLUSIONS: This study shows that dietary intakes of preformed VA and pro-VA carotenoids based on 24-h dietary recall method cannot be used as proxy of serum retinol and carotenoid concentrations in this population.
BACKGROUND: The study was registered retrospectively (22 March 2018) as a clinical trial with the Pan African Clinical Trials Registry (Cochrane South Africa; PACTR201803002999356).
摘要：
目的：本研究旨在评估布基纳法索农村地区36-59个月大的儿童膳食摄入预制维生素A（VA）和前VA类胡萝卜素与血清视黄醇和类胡萝卜素浓度之间的关系。
方法：在布基纳法索的农村地区进行了两项基于社区的横断面研究，包括115名36-59个月的儿童。通过24小时饮食回忆直接评估预先形成的VA和pro-VA的饮食摄入量。血清视黄醇和类胡萝卜素(α-和β-胡萝卜素，和β-隐黄质）浓度进行了测量。通过多元线性回归评估血清视黄醇和类胡萝卜素浓度与其各自的饮食摄入量之间的关联。
结果：几何平均[95％CI]调整后的儿童血清视黄醇浓度为0.86[0.81;0.92]µmol/L。低调整血清视黄醇浓度(<0.7μmol/L)的患病率为26.8%。几何平均[95%CI]血清类胡萝卜素浓度为：α-胡萝卜素（0.03[0.02;0.03]µmol/L），β-胡萝卜素（0.14[0.12;0.16]µmol/L），和β-隐黄质（0.17[0.15;0.21]µmol/L）。在雨季，饮食中α-和β-胡萝卜素的摄入量以及调整后的血清视黄醇和α-胡萝卜素浓度明显更高。在多元线性回归中，在布基纳法索,36~59个月的儿童中,饮食中预先形成的VA和VA前的类胡萝卜素摄入量与血清视黄醇和类胡萝卜素浓度之间未发现相关性.季节对预先形成的VA和pro-VA类胡萝卜素摄入量与血清视黄醇和类胡萝卜素浓度之间的关联没有影响。
结论：这项研究表明，基于24小时饮食召回方法的预先形成的VA和pro-VA类胡萝卜素的饮食摄入量不能用作该人群中血清视黄醇和类胡萝卜素浓度的替代。
背景：该研究作为一项临床试验在泛非临床试验注册中心（CochraneSouthAfrica;PACTR201803002999356）进行了回顾性注册（2018年3月22日）。
方法：在布基纳法索的农村地区进行了两项基于社区的横断面研究，包括115名36-59个月的儿童。通过24小时饮食回忆直接评估预先形成的VA和pro-VA的饮食摄入量。血清视黄醇和类胡萝卜素(α-和β-胡萝卜素，和β-隐黄质）浓度进行了测量。通过多元线性回归评估血清视黄醇和类胡萝卜素浓度与其各自的饮食摄入量之间的关联。
结果：几何平均[95％CI]调整后的儿童血清视黄醇浓度为0.86[0.81;0.92]µmol/L。低调整血清视黄醇浓度(<0.7μmol/L)的患病率为26.8%。几何平均[95%CI]血清类胡萝卜素浓度为：α-胡萝卜素（0.03[0.02;0.03]µmol/L），β-胡萝卜素（0.14[0.12;0.16]µmol/L），和β-隐黄质（0.17[0.15;0.21]µmol/L）。在雨季，饮食中α-和β-胡萝卜素的摄入量以及调整后的血清视黄醇和α-胡萝卜素浓度明显更高。在多元线性回归中，在布基纳法索,36~59个月的儿童中,饮食中预先形成的VA和VA前的类胡萝卜素摄入量与血清视黄醇和类胡萝卜素浓度之间未发现相关性.季节对预先形成的VA和pro-VA类胡萝卜素摄入量与血清视黄醇和类胡萝卜素浓度之间的关联没有影响。
结论：这项研究表明，基于24小时饮食召回方法的预先形成的VA和pro-VA类胡萝卜素的饮食摄入量不能用作该人群中血清视黄醇和类胡萝卜素浓度的替代。
背景：该研究作为一项临床试验在泛非临床试验注册中心（CochraneSouthAfrica;PACTR201803002999356）进行了回顾性注册（2018年3月22日）。
