PDF(Pubmed)
Abstract：
Background: Limited information is currently available on the natural history and prognosis of two distinct histological subtypes of adenocarcinoma (AC) in the colon: mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC). Therefore, the aim of this study is to examine the clinicopathological characteristics of colon MAC and SRCC, comparing them to classical AC, using a large cohort of cases from the United States. Methods: Patients diagnosed with colon AC, MAC, or SRCC from the SEER database between 2000 and 2018 were included in our study. Incidence trends, patient demographics, tumor characteristics, treatment, and survival were analyzed. Results: In our study, we analyzed a total of 310,813 patients with colon cancers, including 271,382 cases of classical AC, 34,750 cases of MAC, and 4,681 cases of SRCC. Over the study period, we observed a decline in the age-adjusted incidence rates of colon AC, MAC, and SRCC. Notably, the MAC and SRCC cohorts differed significantly from AC in terms of patient characteristics, tumor locations, and treatment patterns. Patients with MAC and SRCC had poorer survival outcomes compared to those with AC. Factors associated with worse survival included older age, male sex, poorly differentiated tumors, advanced stage, and the presence of MAC or SRCC histology. On the other hand, surgical intervention was associated with improved survival. Conclusion: Our study underscores the significance of recognizing the distinct features and outcomes associated with different histological subtypes of colon cancer. Further research is warranted to delve into the underlying biological traits that contribute to these differences and to develop more tailored treatment strategies.
摘要：
背景：目前有关结肠腺癌（AC）的两种不同组织学亚型的自然史和预后的信息有限：粘液腺癌（MAC）和印戒细胞癌（SRCC）。因此,这项研究的目的是检查结肠MAC和SRCC的临床病理特征，将它们与经典的AC进行比较，使用来自美国的大量病例。方法:诊断为结肠AC的患者,MAC,我们的研究包括2000年至2018年SEER数据库中的SRCC.发病率趋势,患者人口统计学，肿瘤特征，治疗,和生存进行了分析。结果：在我们的研究中，我们分析了310,813例结肠癌患者，包括271,382例经典AC，34,750例MAC，和4,681例SRCC。在学习期间，我们观察到年龄调整后的结肠AC发病率下降，MAC,SRCC。值得注意的是,MAC和SRCC队列在患者特征方面与AC显著不同，肿瘤位置，和治疗模式。与AC患者相比，MAC和SRCC患者的生存结果较差。与生存率较差相关的因素包括年龄较大，男性,低分化肿瘤,高级阶段,以及MAC或SRCC组织学的存在。另一方面,手术干预与生存率改善相关.结论：我们的研究强调了识别与结肠癌不同组织学亚型相关的不同特征和结局的重要性。有必要进行进一步的研究，以深入研究导致这些差异的潜在生物学特征，并制定更量身定制的治疗策略。
