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Abstract：
This study aimed to assess the correlation among the peak intensity (PI) values of quantitative parameters, microvessel density (MVD), microvessel maturity, and International Society of Urological Pathology (ISUP) grades in biopsy specimens from prostate cancer (PCa) patients. The study population included PCa patients who underwent targeted and systematic biopsy, without radiation or chemohormonal therapy before biopsy. Contrast-enhanced transrectal ultrasonography (CE-TRUS) was performed in all patients before biopsy. Contrast-enhancement patterns and PI values of quantitative parameters were observed. Tumor tissue samples were immunostained for CD31 expression. MVD, microvessel maturity, and ISUP grades were determined in prostate biopsy specimens. Based on the contrast enhancement patterns of prostate lesions, 16 patients were assigned to a low-enhancement group and 45 to a high-enhancement group. The number of mature vessels, MVD, mature vessel index, and ISUP grades were all higher in the high-enhancement group than in the low-enhancement group (all P < 0.05). The immature vessel index was lower in the high-enhancement group than in the low-enhancement group (P < 0.05). The PI value was positively correlated with the number of mature vessels (r = 0.372). In conclusion, enhancement patterns on CE-TRUS can reflect microvessel maturity in PCa. The PI value was positively correlated with the number of mature vessels.
摘要：
本研究旨在评估定量参数的峰强度（PI）值之间的相关性，微血管密度（MVD），微血管成熟度,和国际泌尿外科病理学会（ISUP）在前列腺癌（PCa）患者的活检标本中进行分级。研究人群包括接受靶向和系统活检的PCa患者，活检前没有放射或化学激素治疗。所有患者在活检前均进行了经直肠超声造影（CE-TRUS）。观察到定量参数的对比度增强模式和PI值。对肿瘤组织样品进行CD31表达免疫染色。MVD,微血管成熟度,在前列腺活检标本中确定ISUP等级。根据前列腺病变的对比增强模式,16名患者被分配到低增强组，45名患者被分配到高增强组。成熟船只的数量，MVD,成熟血管指数，高强化组及ISUP分级均高于低强化组(均P<0.05)。高强化组未成熟血管指数低于低强化组(P<0.05)。PI值与成熟血管数呈正相关(r=0.372)。总之,CE-TRUS上的增强模式可以反映PCa中微血管的成熟度。PI值与成熟血管数呈正相关。
