Abstract：
BACKGROUND: Patients with peripheral arterial disease (PAD) have a poorer prognosis than those without PAD. PAD complications worsen the prognosis of patients with chronic kidney disease (CKD), especially those on maintenance dialysis. Although low-density lipoprotein apheresis (LDL-A) is expected to be effective in treating severe PAD, there are no large-scale reports on the prognosis of patients undergoing LDL-A.
METHODS: We obtained a clinical database from April 2008 to August 2021 and selected 924 238 patients with CKD. We selected patients with disease codes of lower limb arteriosclerosis obliterans, arteriosclerosis obliterans, and critical limb ischemia or foot ulcer. Patients who were prescribed antithrombotic medications were included. Patients who used steroids were excluded. Among these patients, those undergoing blood purification considered LDL-A were selected, and their current status was investigated.
RESULTS: We included 147 patients (113 males and 34 females). The mean patient age was 70 ± 10 years. Diabetes mellitus was present in 86%, ischemic heart disease in 34%, and stroke in 48%. Maintenance dialysis patients accounted for 86% of the patients. Statins were administered to 40% of the patients, and bypass surgery was performed in 2.7%. The median observation period was 812 days, and the mortality rate was 41%.
CONCLUSIONS: LDL-A was performed in a small population of patients with CKD with the most severe form of PAD. The prognosis for these patients is extremely poor. Therefore, strategies to improve prognosis are important.
METHODS: We obtained a clinical database from April 2008 to August 2021 and selected 924 238 patients with CKD. We selected patients with disease codes of lower limb arteriosclerosis obliterans, arteriosclerosis obliterans, and critical limb ischemia or foot ulcer. Patients who were prescribed antithrombotic medications were included. Patients who used steroids were excluded. Among these patients, those undergoing blood purification considered LDL-A were selected, and their current status was investigated.
RESULTS: We included 147 patients (113 males and 34 females). The mean patient age was 70 ± 10 years. Diabetes mellitus was present in 86%, ischemic heart disease in 34%, and stroke in 48%. Maintenance dialysis patients accounted for 86% of the patients. Statins were administered to 40% of the patients, and bypass surgery was performed in 2.7%. The median observation period was 812 days, and the mortality rate was 41%.
CONCLUSIONS: LDL-A was performed in a small population of patients with CKD with the most severe form of PAD. The prognosis for these patients is extremely poor. Therefore, strategies to improve prognosis are important.
摘要：
背景：患有外周动脉疾病（PAD）的患者比没有PAD的患者预后较差。PAD并发症恶化了慢性肾脏病(CKD)患者的预后,尤其是那些维持透析的人.尽管低密度脂蛋白单采术（LDL-A）有望有效治疗严重的PAD，没有关于接受LDL-A的患者预后的大规模报道。
方法：我们获得了2008年4月至2021年8月的临床数据库，选择了924238例CKD患者。我们选择了患有下肢动脉硬化闭塞症疾病代码的患者，动脉硬化闭塞症，和严重的肢体缺血或足部溃疡。包括接受抗血栓药物治疗的患者。排除使用类固醇的患者。在这些患者中,选择那些接受血液净化的人考虑LDL-A，并调查了他们的现状。
结果：我们包括147例患者（男性113例，女性34例）。患者平均年龄为70±10岁。糖尿病占86%，缺血性心脏病占34%，中风占48%。维持性透析患者占患者的86%。40%的患者服用他汀类药物，和旁路手术的2.7％。中位观察期为812天，死亡率为41%。
结论：LDL-A是在少数CKD患者中进行的，CKD的形式最严重。这些患者的预后极差。因此,改善预后的策略很重要。
方法：我们获得了2008年4月至2021年8月的临床数据库，选择了924238例CKD患者。我们选择了患有下肢动脉硬化闭塞症疾病代码的患者，动脉硬化闭塞症，和严重的肢体缺血或足部溃疡。包括接受抗血栓药物治疗的患者。排除使用类固醇的患者。在这些患者中,选择那些接受血液净化的人考虑LDL-A，并调查了他们的现状。
结果：我们包括147例患者（男性113例，女性34例）。患者平均年龄为70±10岁。糖尿病占86%，缺血性心脏病占34%，中风占48%。维持性透析患者占患者的86%。40%的患者服用他汀类药物，和旁路手术的2.7％。中位观察期为812天，死亡率为41%。
结论：LDL-A是在少数CKD患者中进行的，CKD的形式最严重。这些患者的预后极差。因此,改善预后的策略很重要。
