Abstract：
The toxicity criteria of the veterinary radiation therapy oncology group (VRTOG) version 2 guidelines are a substantial update to reflect significant advances in radiation oncology over the last three decades. Radiation therapy techniques provide precise and spatially accurate radiation delivery, which facilitates treating tumors in more anatomic locations and incorporating hypofractionated protocols. The purpose of this update is to aid radiation oncology teams in capturing and grading clinically relevant data that impacts the decision-making process in everyday practice and the assessment of clinical trials involving radiation therapy. A dedicated committee initially updated the criteria to include more anatomical sites and grades to characterize a broad spectrum of possible radiation-induced acute and late tissue changes. Through the revision process, which solicited and incorporated feedback from all radiation oncologists within the American College of Veterinary Radiology (ACVR) and specialists outside the ACVR, the authors endeavored to create a grading structure reflective of clinical decision-making in daily radiation oncology. The updated VRTOG v2 toxicity criteria guideline complements the updated Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) guidelines. Because radiation oncology continues to progress rapidly, the VRTOG toxicity criteria should be regularly updated as adverse event data that will be collected following this update further informs the practice of radiation oncology.
摘要：
兽医放射治疗肿瘤学组（VRTOG）第2版指南的毒性标准是一项重大更新，以反映过去三十年来放射肿瘤学的重大进展。放射治疗技术提供精确和空间准确的辐射输送，这有助于在更多的解剖位置治疗肿瘤，并纳入大分割方案。本次更新的目的是帮助放射肿瘤学团队捕获和分级临床相关数据，这些数据会影响日常实践中的决策过程以及评估涉及放射治疗的临床试验。一个专门的委员会最初更新了标准，以包括更多的解剖部位和等级，以表征广泛的可能的辐射引起的急性和晚期组织变化。通过修订过程，它征求并纳入了美国兽医放射学学院（ACVR）内的所有放射肿瘤学家和ACVR以外的专家的反馈，作者努力创建反映日常放射肿瘤学临床决策的分级结构.更新的VRTOGv2毒性标准指南补充了更新的兽医合作肿瘤学组-不良事件通用术语标准（VCOG-CTCAEv2）指南。因为放射肿瘤学继续快速发展，VRTOG毒性标准应定期更新,因为更新后收集的不良事件数据将进一步为放射肿瘤学实践提供信息.
