UNASSIGNED: Twenty-three subject-matter experts, divided into three groups, analyzed the two scenarios as part of a multidimensional consensus process, developing statements for specific domains of the disease, and a simplified Delphi methodology was used to establish consensus among the experts.
UNASSIGNED: Recommended actions included increasing awareness of the disease, increased training of healthcare professionals, improvement of screening strategies and care pathways, increased support for patients and caregivers and relevant recommendations from molecular tumor boards when comprehensive genomic profiling has to be provided for appropriate patient selection to ad hoc targeted therapies.
UNASSIGNED: While the innovative new targeted agents have the potential to significantly alter the clinical approach to this highly aggressive disease, the U-CHANGE Project experience shows that the use of these new agents will require a radical shift in the entire model of care, implementing sustainable changes which anticipate the benefits of future treatments, capable of targeting the right patient with the right agent at different stages of the disease.
■二十三名主题专家,分成三组,作为多维共识过程的一部分,分析了这两种情况,为疾病的特定领域制定声明,并使用简化的德尔菲方法在专家之间建立共识。
■建议采取的行动包括提高对这种疾病的认识,加强对医疗保健专业人员的培训,改善筛查策略和护理途径,增加对患者和护理人员的支持以及分子肿瘤委员会的相关建议,因为必须提供全面的基因组分析,以便适当选择患者以进行特定的靶向治疗。
虽然创新的新靶向药物有可能显著改变这种高度侵袭性疾病的临床方法,U-CHANGE项目的经验表明,使用这些新药物将需要整个护理模式的根本性转变,实施可持续的变化,预测未来治疗的好处,能够在疾病的不同阶段用正确的药物靶向正确的患者。