PDF(Pubmed)
Abstract：
Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will precisely enhance osseointegration and bone repair without the systemic side effects. However, an elaborate and comprehensive review of BP coatings of implants is lacking. Herein, the cellular level (e.g., osteoclasts, osteocytes, osteoblasts, osteoclast precursors, and bone mesenchymal stem cells) and molecular biological regulatory mechanism of BPs in regulating bone homeostasis are overviewed systematically. Moreover, the currently available methods (e.g., chemical reaction, porous carriers, and organic material films) of BP coatings construction are outlined and summarized in detail. As one of the key directions, the latest advances of BP-coated implants to enhance bone repair and osseointegration in basic experiments and clinical trials are presented and critically evaluated. Finally, the challenges and prospects of BP coatings are also purposed, and it will open a new chapter in clinical translation for BP-coated implants.
摘要：
双膦酸盐（BPs），焦磷酸盐的稳定类似物，是众所周知的破骨细胞生成抑制剂，可预防骨质疏松性骨丢失并改善患有骨质疏松症的患者的植入物骨整合。与全身给药相比，BPs-incorporatedcoatingsenablethedirectdeliveryofBPstothelocalarea,这将精确地增强骨整合和骨修复而没有全身副作用。然而,缺乏对植入物BP涂层的详细和全面的审查。在这里，细胞水平(例如，破骨细胞,骨细胞,成骨细胞，破骨细胞前体，和骨髓间充质干细胞）和BPs调节骨稳态的分子生物学调节机制。此外，当前可用的方法(例如，化学反应,多孔载体,和有机材料薄膜）对BP涂层结构进行了概述和详细总结。作为关键方向之一，介绍了BP涂层植入物在基础实验和临床试验中增强骨修复和骨整合的最新进展，并对其进行了严格评估。最后,还提出了BP涂料的挑战和前景，它将为BP涂层植入物的临床翻译开辟新的篇章。
