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Abstract：
The present study aimed to investigate the effect of local oxygen therapy combined with vacuum sealing drainage (VSD) on the healing of stage IV pressure ulcers sacrococcygeal. In this prospective study, we included a total of 98 patients with stage IV sacrococcygeal pressure ulcers in our hospital between February 2021 and June 2022. The patients enrolled were randomly and equally divided into two groups: the study group (undergoing local oxygen therapy combined with VSD treatment) and the control group (receiving conventional treatment). The wound healing time and hospital stay were compared between the two groups. Additionally, the wound area, tissue type, wound exudation and pain intensity were assessed before treatment, 10, 20, 30 and 40 days after treatment. The incidence of complications was also calculated. The study group demonstrated significantly shorter wound healing time and hospital stays compared to the control group (p < 0.05). Before treatment, there were no significant differences in terms of wound area, tissue type and wound exudation between the two groups (p > 0.05); after 10, 20, 30 and 40 days of treatment, however, evidently smaller wound areas, improved tissue types and reduced wound exudation were observed in the study group compared to the control group (p < 0.05). Furthermore, the study group exhibited increased microvascular count compared to the control group (p < 0.05). Before treatment, there was no significant difference in pain intensity between the two groups (p > 0.05), whereas markedly lower pain intensity was seen in the study group than in the control group after 10, 20, 30 and 40 days of treatment (p < 0.05). The incidence of complications did not significantly differ between the two groups after 40 days of treatment (p > 0.05). Local oxygen therapy combined with VSD was found to effectively accelerate the healing process of stage IV sacrococcygeal pressure ulcers, leading to shorter hospital stays and improved patient prognosis. This combined therapy shows promise for widespread application in clinical practice.
摘要：
本研究旨在探讨局部氧疗联合负压封闭引流(VSD)对骶尾部Ⅳ期压疮愈合的影响。在这项前瞻性研究中，我们纳入了2021年2月至2022年6月期间在我们医院治疗的98例IV期骶尾部压迫性溃疡患者.将入选患者随机等分为两组：研究组（接受局部氧疗联合VSD治疗）和对照组（接受常规治疗）。比较两组创面愈合时间及住院时间。此外,伤口区域,组织类型,治疗前评估伤口渗出和疼痛强度，治疗后10、20、30和40天。还计算了并发症的发生率。与对照组相比，研究组的伤口愈合时间和住院时间明显缩短（p<0.05）。治疗前,伤口面积没有显着差异，两组间组织类型及创面渗出情况(p>0.05);治疗10、20、30、40天,然而,伤口面积明显较小,与对照组相比，研究组组织类型改善，伤口渗出减少（p<0.05）。此外，与对照组相比,研究组微血管计数增加(p<0.05).治疗前,两组患者疼痛强度差异无统计学意义(p>0.05),治疗10、20、30和40天后，研究组的疼痛强度明显低于对照组（p<0.05）。两组治疗40天后并发症发生率差异无统计学意义(p>0.05)。发现局部氧疗联合VSD可有效加速IV期骶尾部压疮的愈合过程,缩短住院时间，改善患者预后。这种联合疗法有望在临床实践中广泛应用。
