PDF(Pubmed)
Abstract：
Current treatments for chronic pain are inadequate. Here, we provide an update on the new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a better and safer treatment of chronic pain.
Despite the complex nature of chronic pain and its underlying mechanisms, we do know that changes in the plasticity and modality of neurons in DRGs play a pivotal role. DRG neurons are heterogenous and offer potential pain targets for different therapeutic interventions. We discuss the last advancements of these interventions, which include the use of systemic and local administrations, selective nerve drug delivery, and gene therapy. In particular, we provide updates and further details on the molecular characterization of primary sensory neurons, new analgesics entering the market, and future gene therapy approaches.
DRGs and primary sensory neurons are promising targets for chronic pain treatment due to their key role in pain signaling, unique anatomical location, and the potential for different targeted therapeutic interventions.
Despite the complex nature of chronic pain and its underlying mechanisms, we do know that changes in the plasticity and modality of neurons in DRGs play a pivotal role. DRG neurons are heterogenous and offer potential pain targets for different therapeutic interventions. We discuss the last advancements of these interventions, which include the use of systemic and local administrations, selective nerve drug delivery, and gene therapy. In particular, we provide updates and further details on the molecular characterization of primary sensory neurons, new analgesics entering the market, and future gene therapy approaches.
DRGs and primary sensory neurons are promising targets for chronic pain treatment due to their key role in pain signaling, unique anatomical location, and the potential for different targeted therapeutic interventions.
摘要：
■目前对慢性疼痛的治疗是不充分的。这里,我们提供了针对周围神经系统背根神经节(DRGs)的新治疗策略的更新,以更好,更安全地治疗慢性疼痛.
■尽管慢性疼痛的性质及其潜在机制复杂，我们知道DRGs中神经元的可塑性和形态的变化起着关键作用。DRG神经元是异质性的，为不同的治疗干预提供了潜在的疼痛靶点。我们讨论了这些干预措施的最后进展，其中包括使用系统和地方政府，选择性神经药物递送，和基因治疗。特别是,我们提供了初级感觉神经元的分子表征的更新和进一步的细节，新的镇痛药进入市场，和未来的基因治疗方法。
■DRGs和初级感觉神经元由于其在疼痛信号传导中的关键作用，是慢性疼痛治疗的有希望的目标。独特的解剖位置，以及不同针对性治疗干预措施的潜力。
■尽管慢性疼痛的性质及其潜在机制复杂，我们知道DRGs中神经元的可塑性和形态的变化起着关键作用。DRG神经元是异质性的，为不同的治疗干预提供了潜在的疼痛靶点。我们讨论了这些干预措施的最后进展，其中包括使用系统和地方政府，选择性神经药物递送，和基因治疗。特别是,我们提供了初级感觉神经元的分子表征的更新和进一步的细节，新的镇痛药进入市场，和未来的基因治疗方法。
■DRGs和初级感觉神经元由于其在疼痛信号传导中的关键作用，是慢性疼痛治疗的有希望的目标。独特的解剖位置，以及不同针对性治疗干预措施的潜力。
