Abstract：
BACKGROUND: Brief interventions for alcohol use disorder (AUD) are generally efficacious, albeit with variability in response. Resting state functional connectivity (rsFC) may characterize neurobiological indicators that predict the response to brief interventions and is the focus of the current investigation.
METHODS: Forty-six individuals with AUD (65.2% female) completed a resting state functional magnetic resonance imaging (fMRI) scan immediately followed by a brief intervention aimed at reducing alcohol consumption. Positive clinical response was defined as a reduction in alcohol consumption by at least one World Health Organization (WHO) risk drinking level at 3-month follow-up. rsFC was analyzed using seed-to-voxel analysis with seed regions from four networks: salience network, reward network, frontoparietal network, and default mode network.
RESULTS: At baseline, responders had greater rsFC between the following seed regions in relation to voxel-based clusters than non-responders: (i) anterior cingulate cortex (ACC) in relation to left postcentral gyrus and right supramarginal gyrus (salience network); (ii) right posterior parietal cortex in relation to right ventral ACC (salience network); (iii) right interior frontal gyrus (IFG) pars opercularis in relation to right cerebellum and right occipital fusiform gyrus (frontoparietal); and (iv) right primary motor cortex in relation to left thalamus (default mode). Lower rsFC in responders vs. nonresponders was seen between the (i) right rostral prefrontal cortex in relation to left IFG pars triangularis (frontoparietal); (ii) right IFG pars triangularis in relation to right cerebellum (frontoparietal); (iii) right IFG pars triangularis in relation to right frontal eye fields and right angular gyrus (frontoparietal); and (iv) right nucleus accumbens in relation to right orbital frontal cortex and right insula (reward).
CONCLUSIONS: Resting state functional connectivity in the frontoparietal, salience, and reward networks predicts the response to a brief intervention in individuals with AUD and could reflect greater receptivity or motivation for behavior change.
METHODS: Forty-six individuals with AUD (65.2% female) completed a resting state functional magnetic resonance imaging (fMRI) scan immediately followed by a brief intervention aimed at reducing alcohol consumption. Positive clinical response was defined as a reduction in alcohol consumption by at least one World Health Organization (WHO) risk drinking level at 3-month follow-up. rsFC was analyzed using seed-to-voxel analysis with seed regions from four networks: salience network, reward network, frontoparietal network, and default mode network.
RESULTS: At baseline, responders had greater rsFC between the following seed regions in relation to voxel-based clusters than non-responders: (i) anterior cingulate cortex (ACC) in relation to left postcentral gyrus and right supramarginal gyrus (salience network); (ii) right posterior parietal cortex in relation to right ventral ACC (salience network); (iii) right interior frontal gyrus (IFG) pars opercularis in relation to right cerebellum and right occipital fusiform gyrus (frontoparietal); and (iv) right primary motor cortex in relation to left thalamus (default mode). Lower rsFC in responders vs. nonresponders was seen between the (i) right rostral prefrontal cortex in relation to left IFG pars triangularis (frontoparietal); (ii) right IFG pars triangularis in relation to right cerebellum (frontoparietal); (iii) right IFG pars triangularis in relation to right frontal eye fields and right angular gyrus (frontoparietal); and (iv) right nucleus accumbens in relation to right orbital frontal cortex and right insula (reward).
CONCLUSIONS: Resting state functional connectivity in the frontoparietal, salience, and reward networks predicts the response to a brief intervention in individuals with AUD and could reflect greater receptivity or motivation for behavior change.
摘要：
背景：对酒精使用障碍（AUD）的简短干预通常是有效的，尽管反应有可变性。静息状态功能连通性（rsFC）可以表征预测对短暂干预的反应的神经生物学指标，并且是当前研究的重点。
方法：46名AUD患者（65.2％女性）立即完成了静息状态功能磁共振成像（fMRI）扫描，随后进行了旨在减少饮酒的简短干预。积极的临床反应被定义为在3个月的随访中，至少有一个世界卫生组织（WHO）的饮酒风险水平降低了饮酒。使用种子到体素分析对来自四个网络的种子区域进行rsFC分析：显著性网络，奖励网络，额顶叶网络，和默认模式网络。
结果：在基线时，与基于体素的簇相比，反应者在以下种子区域之间的rsFC更大：（i）前扣带皮层（ACC）与左中央后回和右上回（salencenetwork）有关；（ii）右后顶叶皮层与右腹侧ACC（salencenetwork）有关；（iii）右内额叶（IFG）与右脑的关系响应者与响应者的rsFC较低在（i）与左三角IFG旁（额顶）有关的右前额叶前额叶皮层之间观察到无反应者；（ii）与右小脑有关的右三角IFG旁（额顶）；（iii）与右额叶岛叶和右伏额回（额顶）有关的右三角IFG旁；（右脑）与右脑叶的关系。
结论：额顶叶的静息状态功能连接，显著性,和奖励网络可预测AUD个体对短暂干预的反应，并可能反映出更大的接受性或行为改变的动机。
方法：46名AUD患者（65.2％女性）立即完成了静息状态功能磁共振成像（fMRI）扫描，随后进行了旨在减少饮酒的简短干预。积极的临床反应被定义为在3个月的随访中，至少有一个世界卫生组织（WHO）的饮酒风险水平降低了饮酒。使用种子到体素分析对来自四个网络的种子区域进行rsFC分析：显著性网络，奖励网络，额顶叶网络，和默认模式网络。
结果：在基线时，与基于体素的簇相比，反应者在以下种子区域之间的rsFC更大：（i）前扣带皮层（ACC）与左中央后回和右上回（salencenetwork）有关；（ii）右后顶叶皮层与右腹侧ACC（salencenetwork）有关；（iii）右内额叶（IFG）与右脑的关系响应者与响应者的rsFC较低在（i）与左三角IFG旁（额顶）有关的右前额叶前额叶皮层之间观察到无反应者；（ii）与右小脑有关的右三角IFG旁（额顶）；（iii）与右额叶岛叶和右伏额回（额顶）有关的右三角IFG旁；（右脑）与右脑叶的关系。
结论：额顶叶的静息状态功能连接，显著性,和奖励网络可预测AUD个体对短暂干预的反应，并可能反映出更大的接受性或行为改变的动机。
