PDF(Pubmed)
Abstract：
BACKGROUND Parkinson\'s disease (PD) is a neurodegenerative disorder that often requires long-term management of motor symptoms. Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) has shown promising results in alleviating motor fluctuations and improving quality of life. This study aimed to evaluate the efficacy and safety of transgastric jejunostomy (PEG-J) as a delivery method for LCIG in a cohort of 43 PD patients. MATERIAL AND METHODS Forty-three PD patients who were candidates for LCIG therapy underwent transgastric jejunostomy to facilitate continuous infusion of LCIG. The primary outcomes assessed were motor symptom improvement, reduction in motor fluctuations, and medication-related adverse events. Secondary outcomes included changes in quality of life, dyskinesia severity, and healthcare resource utilization. RESULTS The results of this study demonstrated significant improvements in motor symptoms, reduction in motor fluctuations, and enhanced quality of life following PEG-J for LCIG infusion. The treatment was generally well-tolerated, with a low incidence of procedure-related complications. Notably, the use of PEG-J allowed for precise and continuous delivery of LCIG, minimizing variations in drug absorption and ensuring consistent therapeutic levels. CONCLUSIONS Transgastric jejunostomy (PEG-J) offers an effective approach for the continuous infusion of LCIG in Parkinson\'s disease treatment. This method provides a stable and reliable delivery system, leading to improved symptom control and enhanced quality of life for PD patients.
摘要：
背景技术帕金森病(PD)是一种神经退行性疾病,其通常需要长期管理运动症状。连续输注左旋多巴-卡比多巴肠凝胶（LCIG）在减轻运动波动和改善生活质量方面显示出可喜的结果。本研究旨在评估43例PD患者的经胃空肠造口术（PEG-J）作为LCIG的递送方法的有效性和安全性。材料与方法43例接受LCIG治疗的PD患者接受了经胃空肠造口术，以促进持续输注LCIG。评估的主要结果是运动症状改善，减少电机波动，和药物相关的不良事件。次要结果包括生活质量的变化，运动障碍严重程度，和医疗资源利用。结果这项研究的结果表明，运动症状显着改善，减少电机波动，PEG-J输注LCIG后生活质量提高。治疗一般耐受性良好，与手术相关的并发症发生率低。值得注意的是,PEG-J的使用允许LCIG的精确和连续交付，尽量减少药物吸收的变化，并确保一致的治疗水平。结论经胃空肠造口术(PEG-J)为持续输注LCIG治疗帕金森病提供了一种有效的方法。该方法提供了稳定可靠的输送系统,改善PD患者的症状控制和生活质量。
