PDF(Pubmed)
Abstract：
The relationship between vitamin E intake or circulating α-tocopherol and various health outcomes is still debatable and uncertain. We conducted an umbrella review to identify the relationships between vitamin E intake or circulating tocopherol and health outcomes by merging and recalculating earlier meta-analyses. The connections that were found to be statistically significant were then classified into different evidence levels based on p values, between-study heterogeneity, prediction intervals, and small study effects. We finally included 32 eligible meta-analyses with four vitamin E sources and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheeze or asthma in children was substantiated by consistent evidence. Suggestive evidence was suggested for seven results on endothelial function (supplemental vitamin E): serum C-reactive protein (CRP) concentrations (supplemental vitamin E), cervical cancer (dietary vitamin E), esophageal cancer (dietary vitamin E), cervical intraepithelial neoplasia (CIN, dietary vitamin E), pancreatic cancer (total vitamin E intake), and colorectal cancer (circulating α-tocopherol levels); all of these showed a protective effect consistent with the vitamin E source. In conclusion, our work has indicated that vitamin E is protective for several particular health outcomes. Further prospective studies are required when other factors that may contribute to bias are considered.
摘要：
维生素E摄入或循环α-生育酚与各种健康结果之间的关系仍然存在争议和不确定。通过合并和重新计算早期的荟萃分析，我们进行了一项综述，以确定维生素E摄入量或循环生育酚与健康结果之间的关系。然后根据p值将发现具有统计学意义的连接分为不同的证据级别，研究之间的异质性，预测间隔，和小的研究效果。我们最终纳入了32个合格的荟萃分析，包括4个维生素E来源和64个独特的健康结果。只有循环α-生育酚与儿童喘息或哮喘之间的关联得到一致证据的证实。提示血管内皮功能（补充维生素E）的七个结果：血清C反应蛋白（CRP）浓度（补充维生素E），宫颈癌（膳食维生素E），食管癌（膳食维生素E），宫颈上皮内瘤变（CIN，膳食维生素E)，胰腺癌（总维生素E摄入量），和结肠直肠癌（循环α-生育酚水平）；所有这些都显示出与维生素E来源一致的保护作用。总之,我们的研究表明,维生素E对几种特定的健康结局具有保护作用.当考虑可能导致偏倚的其他因素时，需要进一步的前瞻性研究。
