PDF(Pubmed)
Abstract：
As per the latest ILAE definition, status epilepticus (SE) may lead to long-term irreversible consequences, such as neuronal death, neuronal injury, and alterations in neuronal networks. Consequently, there is growing interest in identifying biomarkers that can demonstrate and quantify the extent of neuronal and glial injury. Despite numerous studies conducted on animal models of status epilepticus, which clearly indicate seizure-induced neuronal and glial injury, as well as signs of atrophy and gliosis, evidence in humans remains limited to case reports and small case series. The implications of identifying such biomarkers in clinical practice are significant, including improved prognostic stratification of patients and the early identification of those at high risk of developing irreversible complications. Moreover, the clinical validation of these biomarkers could be crucial in promoting neuroprotective strategies in addition to antiseizure medications. In this study, we present a systematic review of research on biomarkers of neuro-glial injury in patients with status epilepticus.
摘要：
根据最新的ILAE定义，癫痫持续状态（SE）可能导致长期不可逆的后果，比如神经元死亡，神经元损伤，和神经元网络的改变。因此,人们对鉴定能够证明和量化神经元和神经胶质损伤程度的生物标志物越来越感兴趣.尽管对癫痫持续状态的动物模型进行了大量研究，这清楚地表明癫痫发作引起的神经元和神经胶质损伤，以及萎缩和神经胶质增生的迹象，人类的证据仍然限于病例报告和小病例系列。在临床实践中识别此类生物标志物的意义是重要的，包括改善患者的预后分层和早期识别发生不可逆并发症的高风险患者。此外，除抗癫痫药物外,这些生物标志物的临床验证对于促进神经保护策略也至关重要.在这项研究中,本文对癫痫持续状态患者神经胶质损伤生物标志物的研究进行了系统综述。
