Abstract：
OBJECTIVE: This systematic review aims to evaluate the optimal treatment for male infertility resulting from Anabolic Androgenic Steroids (AAS) abuse.
METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies that compared different protocols for the recovery of spermatogenesis in patients after AAS use were included.
RESULTS: 13 studies investigating different protocols to restore spermatogenesis in patients with AAS abuse met the inclusion criteria. The available agents that showed restoration of spermatogenesis include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their use is still poorly described in the literature.
CONCLUSIONS: Clinicians need to be aware of the detrimental effects of AAS on spermatogenesis. AAS-associated infertility may be reversible, but sperm production may take over a year to normalize. Both conservative and aggressive treatment can boost spermatogenesis with positive results. Further understanding of male reproductive endocrinology and high-quality data on the field of restoration of spermatogenesis after AAS abuse are warranted.
METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies that compared different protocols for the recovery of spermatogenesis in patients after AAS use were included.
RESULTS: 13 studies investigating different protocols to restore spermatogenesis in patients with AAS abuse met the inclusion criteria. The available agents that showed restoration of spermatogenesis include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their use is still poorly described in the literature.
CONCLUSIONS: Clinicians need to be aware of the detrimental effects of AAS on spermatogenesis. AAS-associated infertility may be reversible, but sperm production may take over a year to normalize. Both conservative and aggressive treatment can boost spermatogenesis with positive results. Further understanding of male reproductive endocrinology and high-quality data on the field of restoration of spermatogenesis after AAS abuse are warranted.
摘要：
目的：本系统综述旨在评估由合成代谢雄激素类固醇（AAS）滥用引起的男性不育症的最佳治疗方法。
方法：根据系统评价和荟萃分析（PRISMA）声明的首选报告项目进行系统评价。包括比较使用AAS后患者精子发生恢复的不同方案的研究。
结果：13项研究调查了AAS滥用患者恢复精子发生的不同方案，符合纳入标准。显示精子发生恢复的可用药物包括可注射的促性腺激素，选择性雌激素受体调节剂，和芳香化酶抑制剂，但它们的使用在文献中描述仍然很少。
结论：临床医生需要了解AAS对精子发生的有害影响。AAS相关的不孕症可能是可逆的，但是精子生产可能需要一年以上才能恢复正常。保守和积极的治疗都可以促进精子发生，并取得积极的结果。有必要进一步了解男性生殖内分泌学和AAS滥用后精子发生恢复领域的高质量数据。
方法：根据系统评价和荟萃分析（PRISMA）声明的首选报告项目进行系统评价。包括比较使用AAS后患者精子发生恢复的不同方案的研究。
结果：13项研究调查了AAS滥用患者恢复精子发生的不同方案，符合纳入标准。显示精子发生恢复的可用药物包括可注射的促性腺激素，选择性雌激素受体调节剂，和芳香化酶抑制剂，但它们的使用在文献中描述仍然很少。
结论：临床医生需要了解AAS对精子发生的有害影响。AAS相关的不孕症可能是可逆的，但是精子生产可能需要一年以上才能恢复正常。保守和积极的治疗都可以促进精子发生，并取得积极的结果。有必要进一步了解男性生殖内分泌学和AAS滥用后精子发生恢复领域的高质量数据。
