PDF(Pubmed)
Abstract：
With the improved quality of life, oral health is under increased pressure. Numerous common oral mucosal diseases, such as oral lichen planus(OLP) and gingivitis, are related to the destruction of the oral immune barrier. The cytokines secreted by T-helper 17 (Th17) cells are essential for maintaining oral immune homeostasis and play essential roles in immune surveillance. When antigens stimulate the epithelium, Th17 cells expand, differentiate, and generate inflammatory factors to recruit other lymphocytes, such as neutrophils, to clear the infection, which helps to maintain the integrity of the epithelial barrier. In contrast, excessive Th17/IL-17 axis reactions may cause autoimmune damage. Therefore, an in-depth understanding of the role of Th17 cells in oral mucosa may provide prospects for treating oral mucosal diseases. We reviewed the role of Th17 cells in various oral and skin mucosal systemic diseases with oral characteristics, and based on the findings of these reports, we emphasize that Th17 cellular response may be a critical factor in inflammatory diseases of the oral mucosa. In addition, we should pay attention to the role and relationship of \"pathogenic Th17\" and \"non-pathogenic Th17\" in oral mucosal diseases. We hope to provide a reference for Th17 cells as a potential therapeutic target for treating oral mucosal inflammatory disorders in the future.
摘要：
随着生活质量的提高，口腔健康面临越来越大的压力。许多常见的口腔粘膜疾病，如口腔扁平苔藓（OLP）和牙龈炎，与口腔免疫屏障的破坏有关。辅助性T细胞17（Th17）细胞分泌的细胞因子对于维持口服免疫稳态至关重要，并在免疫监视中发挥重要作用。当抗原刺激上皮时，Th17细胞扩增，区分,并产生炎症因子来招募其他淋巴细胞，比如中性粒细胞，为了清除感染，这有助于维持上皮屏障的完整性。相比之下,过度的Th17/IL-17轴反应可能导致自身免疫损伤。因此,深入了解Th17细胞在口腔黏膜中的作用可能为口腔黏膜疾病的治疗提供前景。我们综述了Th17细胞在具有口腔特征的各种口腔和皮肤黏膜系统疾病中的作用。根据这些报告的结果，我们强调Th17细胞反应可能是口腔粘膜炎性疾病的关键因素。此外,应重视“致病性Th17”和“非致病性Th17”在口腔黏膜疾病中的作用及相互关系。我们希望为未来Th17细胞作为治疗口腔黏膜炎症性疾病的潜在治疗靶点提供参考。
