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Abstract：
Introduction Focal and segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome in both adults and children. The \"Columbia classification of FSGS\" includes five variants; not otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants that may have different prognostic and therapeutic implications. Materials and Methods This is a retrospective study and was carried out in the Department of Histopathology, Apollo Hospitals, Hyderabad. Of a total of 11,691 kidney biopsies over a 7-year period, from 2006 to 2012, 824 cases were diagnosed as FSGS, of which 610 cases in which detailed clinical findings were available were included in this study. FSGS was then categorized according to the Columbia classification. Results FSGS, NOS was the predominant histomorphological variant. Serum creatinine was significantly high in the collapsing variant, followed by NOS. Follow-up data was available for 103 cases,72.8% had complete remission, 10.6% had partial remission, and in 16.5 % there was no remission. Relapses were observed in 6.7% cases, two patients (1.9%) succumbed, and 4.8% cases progressed to chronic kidney disease. Conclusion This study showed that perihilar variant was less prevalent, with tip and cellular variants being more prevalent in Indian subcontinent compared to Western literature. Collapsing variant was also less common.
摘要：
简介局灶性和节段性肾小球硬化（FSGS）是成人和儿童肾病综合征的主要原因。“FSGS的哥伦比亚分类”包括五个变体；未另作说明（NOS），tip,门周,细胞，以及可能具有不同预后和治疗意义的塌陷变体。材料与方法这是一项回顾性研究，在组织病理学部门进行，阿波罗医院,海得拉巴.在7年的总共11,691例肾脏活检中，从2006年到2012年，824例被诊断为FSGS，本研究纳入了610例获得详细临床发现的病例.然后根据哥伦比亚分类对FSGS进行分类。FSGS结果,NOS是主要的组织形态变异。塌陷变种的血清肌酐明显偏高,其次是NOS。有103例病例的随访数据，72.8%完全缓解,10.6%部分缓解,16.5%的患者没有缓解。在6.7％的病例中观察到复发，两名患者(1.9%)死亡,4.8%的病例进展为慢性肾脏病。结论这项研究表明，肺门周围变异不太普遍，与西方文献相比，尖端和细胞变异在印度次大陆更为普遍。塌陷变体也较不常见。
