Abstract：
This prospective observational study investigated the determinants of malignant transformation (MT) in localized oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL).
Demographic, clinical, histological, and DNA ploidy status data were collected at enrolment. Survival analysis was performed (MT being the event of interest).
One-hundred and thirty-three patients with OL and 20 patients with PVL entered the study over 6 years (mean follow-up 7.8 years). The presence of OED, DNA ploidy, clinical presentation, and lesion site were associated with MT in patients with OL in a univariate analysis. In a multivariate model, OED was the strongest predictor of MT in patients with OL. Adding DNA ploidy increased the model\'s predictive power. None of the assessed predictors was associated with MT in patients with PVL.
DNA ploidy might identify a subset OL with low risk or minimal risk of MT, but it does not seem to be a reliable predictor in patients with PVL.
Demographic, clinical, histological, and DNA ploidy status data were collected at enrolment. Survival analysis was performed (MT being the event of interest).
One-hundred and thirty-three patients with OL and 20 patients with PVL entered the study over 6 years (mean follow-up 7.8 years). The presence of OED, DNA ploidy, clinical presentation, and lesion site were associated with MT in patients with OL in a univariate analysis. In a multivariate model, OED was the strongest predictor of MT in patients with OL. Adding DNA ploidy increased the model\'s predictive power. None of the assessed predictors was associated with MT in patients with PVL.
DNA ploidy might identify a subset OL with low risk or minimal risk of MT, but it does not seem to be a reliable predictor in patients with PVL.
摘要：
背景：这项前瞻性观察性研究调查了局部口腔白斑（OL）和增生性疣状白斑（PVL）中恶性转化（MT）的决定因素。
方法：人口统计学，临床,组织学,并在登记时收集DNA倍性状态数据.进行生存分析(MT是感兴趣的事件)。
结果：有130名OL患者和20名PVL患者在6年的时间内进入研究（平均随访7.8年）。OED的存在，DNA倍性,临床表现,单因素分析显示，OL患者的病变部位与MT相关。在多变量模型中，OED是OL患者MT的最强预测因子。添加DNA倍性增加了模型的预测能力。评估的预测因子均与PVL患者的MT无关。
结论：DNA倍性可能鉴定出具有MT低风险或最小风险的OL子集，但它似乎不是PVL患者的可靠预测指标。
方法：人口统计学，临床,组织学,并在登记时收集DNA倍性状态数据.进行生存分析(MT是感兴趣的事件)。
结果：有130名OL患者和20名PVL患者在6年的时间内进入研究（平均随访7.8年）。OED的存在，DNA倍性,临床表现,单因素分析显示，OL患者的病变部位与MT相关。在多变量模型中，OED是OL患者MT的最强预测因子。添加DNA倍性增加了模型的预测能力。评估的预测因子均与PVL患者的MT无关。
结论：DNA倍性可能鉴定出具有MT低风险或最小风险的OL子集，但它似乎不是PVL患者的可靠预测指标。
