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Abstract：
OBJECTIVE: This study aims to investigate the topical steroid regimen after small incision lenticule extraction (SMILE) for its effect on very early restoration of visual quality.
METHODS: A total of 180 patients (360 eyes) who underwent SMILE were enrolled. These patients were randomly assigned to three groups, with 60 patients in each group. The only difference among these three groups was the administration of 0.1% fluorometholone (FML) eye drops within two hours after SMILE: no FML in group A, 0.1% FML once every hour in group B and 0.1% FML once every half hour in group C. The corrected distance visual acuity (CDVA), objective scattering index (OSI), modulation transfer function (MTF) cut-off, Strehl ratio (SR) and incidence of subjective symptoms were evaluated preoperatively, at 2, 4 and 24 h and one week after SMILE.
RESULTS: The CDVA, MTF cut-off and SR values were significantly higher in group C, when compared to the other two groups, at 2 and 4 h after SMILE (p < 0.05). Furthermore, the OSI and incidence of subjective symptoms were significantly lower in group C, when compared to the other two groups, at 2 and 4 h after SMILE (p < 0.05). However, no significant differences in CDVA, MTF cut-off, SR, OSI and the incidence of subjective symptoms were detected among the three groups at 24 h and one week after SMILE (p > 0.05).
CONCLUSIONS: The administration of 0.1% FML eye drops every half hour within two hours after SMILE accelerates the restoration of visual and optical quality, and reduces the incidence of subjective symptoms during the very early phase after surgery.
METHODS: A total of 180 patients (360 eyes) who underwent SMILE were enrolled. These patients were randomly assigned to three groups, with 60 patients in each group. The only difference among these three groups was the administration of 0.1% fluorometholone (FML) eye drops within two hours after SMILE: no FML in group A, 0.1% FML once every hour in group B and 0.1% FML once every half hour in group C. The corrected distance visual acuity (CDVA), objective scattering index (OSI), modulation transfer function (MTF) cut-off, Strehl ratio (SR) and incidence of subjective symptoms were evaluated preoperatively, at 2, 4 and 24 h and one week after SMILE.
RESULTS: The CDVA, MTF cut-off and SR values were significantly higher in group C, when compared to the other two groups, at 2 and 4 h after SMILE (p < 0.05). Furthermore, the OSI and incidence of subjective symptoms were significantly lower in group C, when compared to the other two groups, at 2 and 4 h after SMILE (p < 0.05). However, no significant differences in CDVA, MTF cut-off, SR, OSI and the incidence of subjective symptoms were detected among the three groups at 24 h and one week after SMILE (p > 0.05).
CONCLUSIONS: The administration of 0.1% FML eye drops every half hour within two hours after SMILE accelerates the restoration of visual and optical quality, and reduces the incidence of subjective symptoms during the very early phase after surgery.
摘要：
目的：本研究旨在探讨小切口微透镜摘除（SMILE）后的局部类固醇方案对早期视觉质量恢复的影响。
方法：共纳入180例（360只眼）接受SMILE治疗的患者。这些患者被随机分为三组，每组60例。这三组之间的唯一差异是在SMILE后两小时内给予0.1％氟米龙（FML）滴眼液：A组没有FML，B组0.1%FML每小时1次,C组0.1%FML每半小时1次。目标散射指数（OSI），调制传递函数(MTF)截止,术前评估Strehl比值（SR）和主观症状的发生率，在微笑后2、4和24小时以及一周。
结果：CDVA，C组的MTF截止值和SR值明显高于C组,与其他两组相比，在微笑后2小时和4小时（p<0.05）。此外，C组OSI和主观症状发生率明显较低,与其他两组相比，在微笑后2小时和4小时（p<0.05）。然而,CDVA无显著差异，MTF截止,SR,在SMILE后24h和1周检测到三组的OSI和主观症状的发生率（p>0.05）。
结论：SMILE后两小时内每半小时给药0.1％FML滴眼液可加速视觉和光学质量的恢复，并减少术后早期主观症状的发生率。
方法：共纳入180例（360只眼）接受SMILE治疗的患者。这些患者被随机分为三组，每组60例。这三组之间的唯一差异是在SMILE后两小时内给予0.1％氟米龙（FML）滴眼液：A组没有FML，B组0.1%FML每小时1次,C组0.1%FML每半小时1次。目标散射指数（OSI），调制传递函数(MTF)截止,术前评估Strehl比值（SR）和主观症状的发生率，在微笑后2、4和24小时以及一周。
结果：CDVA，C组的MTF截止值和SR值明显高于C组,与其他两组相比，在微笑后2小时和4小时（p<0.05）。此外，C组OSI和主观症状发生率明显较低,与其他两组相比，在微笑后2小时和4小时（p<0.05）。然而,CDVA无显著差异，MTF截止,SR,在SMILE后24h和1周检测到三组的OSI和主观症状的发生率（p>0.05）。
结论：SMILE后两小时内每半小时给药0.1％FML滴眼液可加速视觉和光学质量的恢复，并减少术后早期主观症状的发生率。
