PDF(Pubmed)
Abstract：
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled proliferation, metastasis, immune evasion and drug resistance of cancer. Targeting trilogy of ECM remodeling could be a new strategy during the early-, middle-, advanced-stages of cancer and overcoming drug resistance. Currently nearly 60% of the alternative anticancer drugs are derived from natural products or active ingredients or structural analogs isolated from plants. According to the characteristics of ECM, this manuscript proposes three phases of whole-process management of cancer, including prevention of cancer development in the early stage of cancer (Phase I); prevent the metastasis of tumor in the middle stage of cancer (Phase II); provide a novel method in the use of immunotherapy for advanced cancer (Phase III), and present novel insights on the contribution of natural products use as innovative strategies to exert anticancer effects by targeting components in ECM. Herein, we focus on trilogy of ECM remodeling and the interaction among ECM, cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), and sort out the intervention effects of natural products on the ECM and related targets in the tumor progression, provide a reference for the development of new drugs against tumor metastasis and recurrence.
摘要：
细胞外基质(ECM)在肿瘤微环境(TME)的构建中起着关键和动态的作用,成为癌症研究和治疗的焦点。ECM重塑中的多细胞信号传导有助于不受控制的增殖，转移,免疫逃避和癌症的耐药性。靶向ECM重塑三部曲可能是早期的一种新策略，middle-,晚期癌症和克服耐药性。目前，近60％的替代抗癌药物来自天然产物或活性成分或从植物中分离的结构类似物。根据ECM的特点,这份手稿提出了癌症全过程管理的三个阶段，包括在癌症早期预防癌症发展（I期）;在癌症中期预防肿瘤转移（II期）;提供一种用于晚期癌症（III期）的免疫疗法的新方法，并提出了关于天然产物的贡献的新见解，这些天然产物用作通过靶向ECM中的成分来发挥抗癌作用的创新策略。在这里，我们关注ECM重塑的三部曲和ECM之间的相互作用，癌症相关成纤维细胞（CAFs）和肿瘤相关巨噬细胞（TAMs），并梳理天然产物在肿瘤进展中对ECM及相关靶点的干预作用,为开发抗肿瘤转移和复发的新药提供参考。
