关键词： (8)F-PBR06 PET Amphiphysin-IgG autoimmunity Facial neuropathy Paraneoplastic mononeuropathies Primary central nervous system lymphoma Sciatic neuropathy

Mesh ： Humans Male Middle Aged Brain / immunology Facial Nerve Diseases / etiology immunology therapy Fluorodeoxyglucose F18 Immunoglobulin G / immunology Positron Emission Tomography Computed Tomography / methods Positron-Emission Tomography / methods Radiopharmaceuticals Receptors, GABA / metabolism Sciatic Neuropathy / etiology immunology therapy Central Nervous System Neoplasms / complications diagnostic imaging immunology Autoimmune Diseases / etiology immunology Lymphoma / complications diagnostic imaging immunology Paraneoplastic Polyneuropathy / etiology immunology Prednisone / therapeutic use Glucocorticoids / therapeutic use Plasma Exchange Nerve Tissue Proteins / immunology

来  源：   DOI：10.1016/j.jneuroim.2023.578156

Abstract：
We reported a 61-year-old man presented with 10-month progressing left sciatic neuropathy and 10-day right facial neuropathy. Serum amphiphysin-IgG was positive. 18F-FDG PET/CT of the whole body showed no signs of malignancy. Treatment with plasma exchange and oral prednisone relieved the symptoms. Nine months later, right hemiparesis and seizure of right limbs developed. 18F-FDG and 18F-PBR06 (18 kDa translocator protein, TSPO) radioligand PET/MRI of the whole body revealed intense uptake in the intracranial lesions. Intracranial lymphoma was diagnosed by stereotactic needle brain biopsy. Mononeuropathies could be paraneoplastic syndromes. TSPO shows high uptake in intracranial lymphoma on 18F-PBR06 PET images.
摘要：
我们报告了一名61岁的男性，患有10个月的进行性左侧坐骨神经病变和10天的右侧面神经病变。血清两栖蛋白IgG阳性。全身18F-FDGPET/CT未见恶性肿瘤征象。血浆置换和口服泼尼松治疗缓解了症状。九个月后,右偏瘫和右肢体癫痫发作。18F-FDG和18F-PBR06（18kDa转运蛋白，TSPO）全身放射配体PET/MRI显示颅内病变强烈摄取。通过立体定向针脑活检诊断颅内淋巴瘤。单神经病可能是副肿瘤综合征。TSPO在18F-PBR06PET图像上显示颅内淋巴瘤的高摄取。
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