Abstract：
Fluorescence nanosensors based on functional nucleic acids have been explored as a powerful sensing platform for disease-relevant miRNAs. This work developed a new hybrid nanosensor (Zr-B) through coordination-driven self-assembly of Zr ions and beacons. The prepared nanosensor exhibited high loading efficiency of beacons and could achieve sensitive and specific detection for miRNAs. The hybrid nanosensor could transfer beacons into living cells efficiently and maintain high stability and biocompatibility in the biological environment, achieving effective miRNA fluorescence imaging in living cells. Therefore, the resultant nanosensor holds potential for applications in disease diagnostics.
摘要：
基于功能性核酸的荧光纳米传感器已被探索为疾病相关miRNA的强大传感平台。这项工作通过Zr离子和信标的配位驱动自组装开发了一种新的混合纳米传感器（Zr-B）。所制备的纳米传感器具有较高的信标加载效率，可以实现对miRNA的灵敏和特异性检测。该混合纳米传感器可以有效地将信标转移到活细胞中，并在生物环境中保持高稳定性和生物相容性，在活细胞中实现有效的miRNA荧光成像。因此,由此产生的纳米传感器具有在疾病诊断中应用的潜力。
