Abstract:
Hyalinising clear cell carcinoma (HCCC) is a rare salivary gland neoplasm characterised by an EWSR1::ATF1 fusion. Rare cases showing EWSR1::CREB1 rearrangements have been reported. This article presents a case of HCCC with a novel EWSR1-CREB1 fusion, diffuse eosinophilic appearance, novel cytomorphological findings, PAS-negativity, and late regional and distant lymph node metastases.
摘要:
透明透明细胞癌(HCCC)是一种罕见的唾液腺肿瘤,其特征是EWSR1::ATF1融合。已经报道了EWSR1::CREB1重排的罕见病例。本文介绍了HCCC与新型EWSR1-CREB1融合的情况,弥漫性嗜酸性粒细胞外观,新的细胞形态学发现,PAS-否定,和晚期区域和远处淋巴结转移。