Abstract：
OBJECTIVE: To assess marginal bone level change (MBLc), clinical outcomes for soft tissue, and survival rates for immediately restored implants with simultaneous guided bone regeneration (GBR).
METHODS: Electronic and manual searches were conducted in PubMed/MEDLINE, EMBASE, and CENTRAL for studies that investigated immediately restored implants in simultaneously grafted sites with a mean follow-up of over 12 months. MBLc was the primary outcome. Soft tissue clinical parameters and implant survival rate (ISR) were the secondary outcomes.
RESULTS: Twenty-five studies (5 randomized controlled trials, 6 prospective studies, 2 retrospective studies, and 12 case series) were included, from which 692 immediately restored implants were analyzed. For studies that investigated bone grafts in the gap between the implant and the peripheral bone wall, the weighted mean MBLc was -0.73 ± 1.52 mm (range: -1.50 to 0.26 mm) for 475 implants. Pink esthetic score (PES) was improved in eight studies and the weighted cumulative ISR was 98.99% (Median: 100%) in 622 implants. Mean MBLc was -1.19 ± 0.26 mm for 30 implants in studies that reported gap with dehiscence and/or fenestration augmentation. Weighted cumulative ISR was 97.25% in 70 implants. A meta-analysis was not possible due to the lack of studies with an eligible control group. Therefore, the data should be interpreted with caution.
CONCLUSIONS: Less marginal bone loss and more predictable soft tissue parameters can be achieved for immediately restored implants with simultaneous peri-implant gap filling compared with gap with dehiscence/fenestration grafting. Increased ISR for implants with gap filling was observed. However, more evidence is needed to confirm whether immediate provisional prostheses should be utilized when bone defects are simultaneously augmented around the implants.
METHODS: Electronic and manual searches were conducted in PubMed/MEDLINE, EMBASE, and CENTRAL for studies that investigated immediately restored implants in simultaneously grafted sites with a mean follow-up of over 12 months. MBLc was the primary outcome. Soft tissue clinical parameters and implant survival rate (ISR) were the secondary outcomes.
RESULTS: Twenty-five studies (5 randomized controlled trials, 6 prospective studies, 2 retrospective studies, and 12 case series) were included, from which 692 immediately restored implants were analyzed. For studies that investigated bone grafts in the gap between the implant and the peripheral bone wall, the weighted mean MBLc was -0.73 ± 1.52 mm (range: -1.50 to 0.26 mm) for 475 implants. Pink esthetic score (PES) was improved in eight studies and the weighted cumulative ISR was 98.99% (Median: 100%) in 622 implants. Mean MBLc was -1.19 ± 0.26 mm for 30 implants in studies that reported gap with dehiscence and/or fenestration augmentation. Weighted cumulative ISR was 97.25% in 70 implants. A meta-analysis was not possible due to the lack of studies with an eligible control group. Therefore, the data should be interpreted with caution.
CONCLUSIONS: Less marginal bone loss and more predictable soft tissue parameters can be achieved for immediately restored implants with simultaneous peri-implant gap filling compared with gap with dehiscence/fenestration grafting. Increased ISR for implants with gap filling was observed. However, more evidence is needed to confirm whether immediate provisional prostheses should be utilized when bone defects are simultaneously augmented around the implants.
摘要：
目的：评估边缘骨水平变化（MBLc），软组织的临床结果，以及同时引导骨再生（GBR）立即恢复的植入物的存活率。
方法：在PubMed/MEDLINE中进行电子和手动搜索，EMBASE,和CENTRAL的研究，调查立即恢复植入物在同时移植部位，平均随访超过12个月。MBLc是主要结果。软组织临床参数和植入物存活率（ISR）是次要结果。
结果：25项研究（5项随机对照试验，6前瞻性研究，2个回顾性研究，和12个病例系列)包括在内，从中分析了692个立即恢复的植入物。对于研究植入物和周围骨壁之间的间隙中的骨移植物的研究，对于475个植入物,加权平均MBLc为-0.73±1.52mm(范围:-1.50~0.26mm).在8项研究中，粉红美学评分（PES）得到了改善，在622个植入物中，加权累积ISR为98.99％（中位数：100％）。在报告有裂开和/或开窗增大的间隙的研究中，30个植入物的平均MBLc为-1.19±0.26mm。70个植入物的加权累积ISR为97.25%。由于缺乏与合格对照组的研究，无法进行荟萃分析。因此,数据应谨慎解释。
结论：与裂开/开窗移植的间隙相比，同时进行种植体周围间隙填充的立即修复植入物可以实现更少的边缘骨丢失和更可预测的软组织参数。观察到具有间隙填充的植入物的ISR增加。然而,当植入物周围的骨缺损同时增加时，需要更多的证据来确认是否应立即使用临时假体。
方法：在PubMed/MEDLINE中进行电子和手动搜索，EMBASE,和CENTRAL的研究，调查立即恢复植入物在同时移植部位，平均随访超过12个月。MBLc是主要结果。软组织临床参数和植入物存活率（ISR）是次要结果。
结果：25项研究（5项随机对照试验，6前瞻性研究，2个回顾性研究，和12个病例系列)包括在内，从中分析了692个立即恢复的植入物。对于研究植入物和周围骨壁之间的间隙中的骨移植物的研究，对于475个植入物,加权平均MBLc为-0.73±1.52mm(范围:-1.50~0.26mm).在8项研究中，粉红美学评分（PES）得到了改善，在622个植入物中，加权累积ISR为98.99％（中位数：100％）。在报告有裂开和/或开窗增大的间隙的研究中，30个植入物的平均MBLc为-1.19±0.26mm。70个植入物的加权累积ISR为97.25%。由于缺乏与合格对照组的研究，无法进行荟萃分析。因此,数据应谨慎解释。
结论：与裂开/开窗移植的间隙相比，同时进行种植体周围间隙填充的立即修复植入物可以实现更少的边缘骨丢失和更可预测的软组织参数。观察到具有间隙填充的植入物的ISR增加。然而,当植入物周围的骨缺损同时增加时，需要更多的证据来确认是否应立即使用临时假体。
