PDF(Pubmed)
Abstract：
Intracranial hemangiopericytoma is a rare invasive tumor originating from mesenchymal fibroblasts and is prone to local recurrence and distant metastasis. This study reports a case of a 27-year-old woman who presented with severe headache, nausea and vomiting for two weeks at thirty-three weeks of gestation. Cranial magnetic resonance imaging (MRI) demonstrated a giant lesion in the bilateral parietal lobe with a size of 5.12x9.19x6.03 cm and severe edema in the surrounding brain tissue. The patient underwent four operations and 3 gamma knife radiosurgery procedures and is recovering well now. The histopathology findings showed hemangiopericytoma and STAT6 and CD34 positivity after the first and second surgeries. Because of tumor progression, the patient received gamma knife radiosurgery at 1, 3, and 4 years after the first operation. Total tumor resection was achieved in the fourth surgery. Nevertheless, the patient showed malignant transformation to from low-grade to high-grade hemangiopericytoma.
摘要：
颅内血管外皮细胞瘤是一种罕见的起源于间质成纤维细胞的侵袭性肿瘤，易发生局部复发和远处转移。这项研究报告了一例27岁的女性，她出现了严重的头痛，妊娠33周时恶心和呕吐两周。颅磁共振成像（MRI）显示双侧顶叶巨大病变，大小为5.12x9.19x6.03cm，周围脑组织严重水肿。该患者接受了4次手术和3次伽玛刀放射外科手术，目前恢复良好。组织病理学发现在第一次和第二次手术后显示血管外皮细胞瘤和STAT6和CD34阳性。因为肿瘤进展,患者在第一次手术后1年,3年和4年接受了伽玛刀放射外科治疗.在第四次手术中实现了肿瘤的完全切除。然而，患者表现为从低度向高度血管外皮细胞瘤的恶性转化.
