PDF(Pubmed)
Abstract：
Periprosthetic joint infections (PJI) following joint arthroplasty are now the leading cause of reoperation and are associated with serious morbidity to the patient, often requiring several staged operations and a prolonged course of parenteral antibiotics. Prophylactic administration of intravenous antibiotics before skin incision is arguably the most important measure to prevent PJI; however, the dose effectiveness of cefazolin in target tissue is not well known. We aimed to identify parameters affecting local tissue concentration (LTC) of cefazolin.
We performed a literature search using the following keywords: \"orthopaedics,\" \"orthopedic,\" \"arthroplasty\" and \"cefazolin.\" We included studies that measured LTC of cefazolin from samples obtained during either a total knee or total hip arthroplasty.
Of the 332 records screened, we included 10 studies that described LTC of cefazolin. The included studies evaluated dosing (n = 7), procedure type (n = 3), body mass index (n = 1) and tourniquet utilization (n = 1).
Few studies have measured LTC levels of antibiotics (or levels of cefazolin) to validate current recommendations for antibiotic prophylaxis in orthopedic surgery. With infection as the leading reason for early reoperation or revision surgery, the parameters affecting LTC during orthopedic procedures need to be further assessed.
We performed a literature search using the following keywords: \"orthopaedics,\" \"orthopedic,\" \"arthroplasty\" and \"cefazolin.\" We included studies that measured LTC of cefazolin from samples obtained during either a total knee or total hip arthroplasty.
Of the 332 records screened, we included 10 studies that described LTC of cefazolin. The included studies evaluated dosing (n = 7), procedure type (n = 3), body mass index (n = 1) and tourniquet utilization (n = 1).
Few studies have measured LTC levels of antibiotics (or levels of cefazolin) to validate current recommendations for antibiotic prophylaxis in orthopedic surgery. With infection as the leading reason for early reoperation or revision surgery, the parameters affecting LTC during orthopedic procedures need to be further assessed.
摘要：
关节置换术后的假体周围关节感染（PJI）现在是再次手术的主要原因，并与患者的严重发病率有关。通常需要几个阶段的手术和长时间的肠胃外抗生素。在皮肤切开之前预防性使用静脉注射抗生素可以说是预防PJI的最重要措施；然而，头孢唑啉在靶组织中的剂量有效性尚不清楚。我们旨在确定影响头孢唑啉局部组织浓度（LTC）的参数。
我们使用以下关键词进行了文献检索：“骨科，\"\"骨科,\"\"关节成形术\"和\"头孢唑啉。“我们纳入了从全膝关节或全髋关节置换术中获得的样本中测量头孢唑啉LTC的研究。
在筛选的332条记录中,我们纳入了10项描述头孢唑啉LTC的研究。纳入的研究评估了剂量(n=7)，程序类型(n=3)，体重指数(n=1)和止血带使用率(n=1)。
很少有研究测量抗生素的LTC水平（或头孢唑林的水平）来验证当前骨科手术中抗生素预防的建议。以感染为主要原因的早期再手术或翻修手术，骨科手术期间影响LTC的参数需要进一步评估.
我们使用以下关键词进行了文献检索：“骨科，\"\"骨科,\"\"关节成形术\"和\"头孢唑啉。“我们纳入了从全膝关节或全髋关节置换术中获得的样本中测量头孢唑啉LTC的研究。
在筛选的332条记录中,我们纳入了10项描述头孢唑啉LTC的研究。纳入的研究评估了剂量(n=7)，程序类型(n=3)，体重指数(n=1)和止血带使用率(n=1)。
很少有研究测量抗生素的LTC水平（或头孢唑林的水平）来验证当前骨科手术中抗生素预防的建议。以感染为主要原因的早期再手术或翻修手术，骨科手术期间影响LTC的参数需要进一步评估.
