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Abstract：
UNASSIGNED: Congenital limb defects (CLD) have a range of phenotypes and can be a substantial cause of disability. The prevalence of CLD in the adult population of Pakistan is not well described.
UNASSIGNED: To investigate the prevalence of CLD and their associated factors in a married female population of the Rahim Yar Khan (RYK) District in Pakistan.
UNASSIGNED: A cross-sectional population-based study was conducted in 4 tehsils of RYK District, and married women and girls from 22 different localities were enrolled by convenience sampling in public places and through door-to-door visits. Data regarding limb phenotype and demographic variables were obtained from participants.
UNASSIGNED: We enrolled 2,204 married women and girls. We found 11 participants with CLD suggesting a prevalence of 4.99/1,000 (proportion: 0.005; 95% confidence interval [CI] <0.001-0.01). Polydactyly was the most frequent (n = 5; prevalence: 2.27/1,000), followed by others in the following sequence: brachydactyly (n = 4; prevalence: 1.81/1,000), camptodactyly (n = 1; prevalence: 0.45/1,000), and oligodactyly (n = 1; prevalence: 0.45/1,000). The odds of occurrence of CLD were higher in individuals originating from Khanpur tehsil (odds ratio [OR] 2.05; 95% CI 0.37-11.27), speaking languages other than Punjabi and Saraiki (OR 2.35; 95% CI 0.24-22.80), belonging to Araien caste (OR 2.35; 95% CI: 0.24-22.80), of a nuclear family (OR 3.35; 95% CI 0.79-16.97), or having parental consanguinity (OR 1.87; 95% CI 0.49-7.06).
UNASSIGNED: Preliminary estimate of CLD prevalence in the married female sample population in RYK appears high compared with estimates from birth defects registries in other countries.
UNASSIGNED: To investigate the prevalence of CLD and their associated factors in a married female population of the Rahim Yar Khan (RYK) District in Pakistan.
UNASSIGNED: A cross-sectional population-based study was conducted in 4 tehsils of RYK District, and married women and girls from 22 different localities were enrolled by convenience sampling in public places and through door-to-door visits. Data regarding limb phenotype and demographic variables were obtained from participants.
UNASSIGNED: We enrolled 2,204 married women and girls. We found 11 participants with CLD suggesting a prevalence of 4.99/1,000 (proportion: 0.005; 95% confidence interval [CI] <0.001-0.01). Polydactyly was the most frequent (n = 5; prevalence: 2.27/1,000), followed by others in the following sequence: brachydactyly (n = 4; prevalence: 1.81/1,000), camptodactyly (n = 1; prevalence: 0.45/1,000), and oligodactyly (n = 1; prevalence: 0.45/1,000). The odds of occurrence of CLD were higher in individuals originating from Khanpur tehsil (odds ratio [OR] 2.05; 95% CI 0.37-11.27), speaking languages other than Punjabi and Saraiki (OR 2.35; 95% CI 0.24-22.80), belonging to Araien caste (OR 2.35; 95% CI: 0.24-22.80), of a nuclear family (OR 3.35; 95% CI 0.79-16.97), or having parental consanguinity (OR 1.87; 95% CI 0.49-7.06).
UNASSIGNED: Preliminary estimate of CLD prevalence in the married female sample population in RYK appears high compared with estimates from birth defects registries in other countries.
摘要：
■先天性肢体缺陷（CLD）具有一系列表型，可能是导致残疾的实质性原因。巴基斯坦成年人口中CLD的患病率尚未得到很好的描述。
■调查巴基斯坦RahimYarKhan（RYK）区已婚女性人群中CLD的患病率及其相关因素。
■在RYK区的4个地方进行了一项基于人群的横断面研究，来自22个不同地区的已婚妇女和女孩通过公共场所的便利抽样和上门访问进行了登记。有关肢体表型和人口统计学变量的数据来自参与者。
■我们登记了2,204名已婚妇女和女孩。我们发现11名CLD患者的患病率为4.99/1,000（比例：0.005；95％置信区间[CI]<0.001-0.01）。多指是最常见的（n=5；患病率：2.27/1,000），其次是以下序列中的其他序列：brachydactyly（n=4；患病率：1.81/1,000），camptodactyly（n=1；患病率：0.45/1,000），和寡牙（n=1；患病率：0.45/1,000）。来自Khanpurtehsil的个体发生CLD的几率较高（优势比[OR]2.05;95％CI0.37-11.27），说旁遮普语和Saraiki以外的其他语言(OR2.35;95%CI0.24-22.80)，属于Araien种姓（OR2.35；95%CI：0.24-22.80），核心家庭(OR3.35；95%CI0.79-16.97)，或有父母血缘关系(OR1.87；95%CI0.49-7.06)。
■与其他国家的出生缺陷登记处的估计相比，RYK已婚女性样本人群中CLD患病率的初步估计似乎很高。
■调查巴基斯坦RahimYarKhan（RYK）区已婚女性人群中CLD的患病率及其相关因素。
■在RYK区的4个地方进行了一项基于人群的横断面研究，来自22个不同地区的已婚妇女和女孩通过公共场所的便利抽样和上门访问进行了登记。有关肢体表型和人口统计学变量的数据来自参与者。
■我们登记了2,204名已婚妇女和女孩。我们发现11名CLD患者的患病率为4.99/1,000（比例：0.005；95％置信区间[CI]<0.001-0.01）。多指是最常见的（n=5；患病率：2.27/1,000），其次是以下序列中的其他序列：brachydactyly（n=4；患病率：1.81/1,000），camptodactyly（n=1；患病率：0.45/1,000），和寡牙（n=1；患病率：0.45/1,000）。来自Khanpurtehsil的个体发生CLD的几率较高（优势比[OR]2.05;95％CI0.37-11.27），说旁遮普语和Saraiki以外的其他语言(OR2.35;95%CI0.24-22.80)，属于Araien种姓（OR2.35；95%CI：0.24-22.80），核心家庭(OR3.35；95%CI0.79-16.97)，或有父母血缘关系(OR1.87；95%CI0.49-7.06)。
■与其他国家的出生缺陷登记处的估计相比，RYK已婚女性样本人群中CLD患病率的初步估计似乎很高。
