PDF(Pubmed)
Abstract：
Objective Biotin is widely known to be beneficial for the hair, nails, and skin, but there are only a few studies on biotin. We evaluated whether there is a relationship between biotin levels and age, gender, and frequently observed laboratory findings. We also evaluated biotin levels according to the reason for checking biotin levels. Methods One hundred five patients applied to the dermatology outpatient clinic and had their biotin levels checked. Patient files were retrospectively analyzed. Results There were a weak positive (r=0.207) relationship between biotin levels and basophil count, a weak positive (r=0.201) relationship between biotin levels and creatinine, and a weak positive (r=0.314) relationship between biotin levels and cholesterol/triglyceride ratio. There were a weak negative (r=-0.216) relationship between biotin levels and mean platelet volume (MPV) and a moderately negative (r=-0.315) relationship between biotin levels and triglyceride levels. Conclusion Biotin levels do not significantly differ with gender but increase with age. Although a weak correlation was detected between hemogram parameters and biotin levels with basophil percentage and mean platelet volume values, biotin did not significantly change hemogram parameters. The relationship between biotin levels and triglyceride levels was the most critical finding of our study. We recommend examining biotin levels in the patients with high triglyceride levels. When we encounter dermatological side effects related to the use of epidermal growth factor receptor tyrosine kinase inhibitors, we recommend evaluating biotin levels. We recommend that biotin supplementation be made only in the patients with deficiencies and that biotin levels be measured in the follow-up.
摘要：
目的众所周知，生物素对头发有益，指甲,和皮肤，但是关于生物素的研究很少。我们评估了生物素水平和年龄之间是否有关系，性别,并经常观察实验室发现。我们还根据检查生物素水平的原因评估了生物素水平。方法对105例皮肤科门诊患者进行生物素水平检查。对患者档案进行回顾性分析。结果生物素水平与嗜碱性粒细胞计数呈弱阳性(r=0.207),生物素水平与肌酐之间存在弱正（r=0.201）关系，生物素水平与胆固醇/甘油三酯比值呈弱正相关(r=0.314)。生物素水平与平均血小板体积（MPV）之间存在弱负（r=-0.216）关系，而生物素水平与甘油三酸酯水平之间存在中度负（r=-0.315）关系。结论生物素水平随性别无明显差异,随年龄增加而升高。尽管在血象参数和生物素水平与嗜碱性粒细胞百分比和平均血小板体积值之间检测到弱相关性,生物素没有显著改变血象参数。生物素水平和甘油三酯水平之间的关系是我们研究中最关键的发现。我们建议检查甘油三酯水平高的患者的生物素水平。当我们遇到与使用表皮生长因子受体酪氨酸激酶抑制剂有关的皮肤病副作用时，我们建议评估生物素水平。我们建议仅在有缺陷的患者中补充生物素，并在随访中测量生物素水平。
