Abstract：
Follicular regulatory T (Tfr) cells play various roles in immune responses, contributing to both positive and negative regulation of foreign antigen-specific B cell responses, control over autoreactive antibody responses and autoimmunity, and B cell class-switching to IgE and allergy development. Studies conducted on mice uncovered various subsets of CXCR5+FoxP3+CD4+ Tfr cells that could differently contribute to immune regulation. Moreover, recent studies of human Tfr cells revealed similar complexity with various subsets of follicular T cells of different origins and immunosuppressive and/or immunostimulatory characteristics. In this review we will overview and compare Tfr subsets currently identified in mice and humans and will discuss their origins and antigen specificity, as well as potential modes of action and contribution to the control of the autoimmune and allergic reactions.
摘要：
卵泡调节T(Tfr)细胞在免疫反应中发挥各种作用，有助于外源抗原特异性B细胞反应的正调节和负调节，控制自身反应性抗体反应和自身免疫，B细胞向IgE的类型转换和过敏的发展。对小鼠进行的研究发现了CXCR5+FoxP3+CD4+Tfr细胞的各种亚群，这些亚群可能对免疫调节有不同的贡献。此外，最近对人类Tfr细胞的研究显示，具有相似的复杂性，具有不同来源的滤泡T细胞的各种亚群以及免疫抑制和/或免疫刺激特性。在这篇综述中，我们将概述和比较目前在小鼠和人类中鉴定的Tfr亚群，并将讨论它们的起源和抗原特异性。以及潜在的作用方式和对控制自身免疫和过敏反应的贡献。
