PDF(Pubmed)
Abstract：
BACKGROUND: Pre-emptive analgesia is expected to decrease post-operative pain. The degree of soft tissue release is directly related to preoperative deformity; we presume the severity of pain has a similar correlation in patients undergoing total knee arthroplasty (TKA). The main purpose of this research was to evaluate the effects of pre-emptive analgesia of different drugs in TKA with different degrees of preoperative genu varus.
METHODS: In this prospective observational study, 67 patients were enrolled with different degrees of genu varus deformity. They were subdivided into two groups: those with ≥15° and those with <15° varus deformities of the knee. Etoricoxib 60 mg and pregabalin 75 mg were administered orally in all the patients as pre-emptive analgesia two hours before surgery. Parameters such as the amount of soft tissue release, visual analog score (VAS), knee range of motion, complications, etc. were documented from the pre-operative period to 72 hours post-TKA.
RESULTS: With pre-emptive analgesia in post-TKA patients, the VAS score demonstrated a statistically significant difference at 24, 48, and 72 hours. The comparison of intraoperative flexion between <15° and ≥15° showed a statistically significant difference with pre-emptive analgesia in post-TKA patients.
CONCLUSIONS: The use of etoricoxib 60 mg and pregabalin 75 mg, two hours before surgery reduced the pain scores in patients undergoing TKA with different degrees of genu varus and correlated with intraoperative parameters associated with soft medial tissue release for genu varus.
METHODS: In this prospective observational study, 67 patients were enrolled with different degrees of genu varus deformity. They were subdivided into two groups: those with ≥15° and those with <15° varus deformities of the knee. Etoricoxib 60 mg and pregabalin 75 mg were administered orally in all the patients as pre-emptive analgesia two hours before surgery. Parameters such as the amount of soft tissue release, visual analog score (VAS), knee range of motion, complications, etc. were documented from the pre-operative period to 72 hours post-TKA.
RESULTS: With pre-emptive analgesia in post-TKA patients, the VAS score demonstrated a statistically significant difference at 24, 48, and 72 hours. The comparison of intraoperative flexion between <15° and ≥15° showed a statistically significant difference with pre-emptive analgesia in post-TKA patients.
CONCLUSIONS: The use of etoricoxib 60 mg and pregabalin 75 mg, two hours before surgery reduced the pain scores in patients undergoing TKA with different degrees of genu varus and correlated with intraoperative parameters associated with soft medial tissue release for genu varus.
摘要：
背景：预控镇痛有望减轻术后疼痛。软组织释放的程度与术前畸形直接相关；我们认为，在接受全膝关节置换术（TKA）的患者中，疼痛的严重程度具有相似的相关性。本研究的主要目的是评估不同药物在不同程度的术前膝内翻TKA中的超前镇痛效果。
方法：在这项前瞻性观察研究中，67例患者均有不同程度的膝内翻畸形。他们分为两组：≥15°的和<15°的膝盖内翻畸形。所有患者均在手术前2小时口服依托考昔60mg和普瑞巴林75mg作为超前镇痛。参数，如软组织释放量，视觉模拟评分(VAS)，膝盖的运动范围，并发症,等。从术前到TKA术后72小时记录。
结果：TKA术后患者采用先发制人镇痛，VAS评分在24,48和72小时有统计学意义的差异.TKA术后患者术中屈曲<15°和≥15°之间的比较显示，与超前镇痛有统计学意义。
结论：使用依托考昔60毫克和普瑞巴林75毫克，手术前2小时可降低接受不同膝内翻的TKA患者的疼痛评分,并与膝内翻的软内侧组织松解相关的术中参数相关.
方法：在这项前瞻性观察研究中，67例患者均有不同程度的膝内翻畸形。他们分为两组：≥15°的和<15°的膝盖内翻畸形。所有患者均在手术前2小时口服依托考昔60mg和普瑞巴林75mg作为超前镇痛。参数，如软组织释放量，视觉模拟评分(VAS)，膝盖的运动范围，并发症,等。从术前到TKA术后72小时记录。
结果：TKA术后患者采用先发制人镇痛，VAS评分在24,48和72小时有统计学意义的差异.TKA术后患者术中屈曲<15°和≥15°之间的比较显示，与超前镇痛有统计学意义。
结论：使用依托考昔60毫克和普瑞巴林75毫克，手术前2小时可降低接受不同膝内翻的TKA患者的疼痛评分,并与膝内翻的软内侧组织松解相关的术中参数相关.
