PDF(Pubmed)
Abstract：
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a complex and heterogeneous disorder affecting various body organs. Menstrual irregularity, anovulation, and many cosmetic issues faced by PCOS patients endanger the essence of being a woman and may have a deleterious impact on their health-related quality of life (HRQOL). This study aimed to assess HRQOL in patients with PCOS and to identify the clinical and socio-demographic factors that might predict poor HRQOL.
METHODS: This cross-sectional study was carried out in the tertiary care hospital in India. A total of 275 women visiting the same setting and diagnosed with PCOS were included. The participants\' quality of life was studied using a disease-specific HRQOL questionnaire. Information regarding clinical and socio-demographics was collected using the interviewer schedule. For evaluating the predictors of HRQOL in PCOS subjects, analysis of variance and independent t-test was applied. For subgroup analysis, the post hoc (Gabriel) test was applied.
RESULTS: The average total score of HRQOL of the study participants was 125.41 ± 29.1. The lowest weighted mean score was for menstrual problems. Among the socio-demographic variables, age and educational level influenced the HRQOL scores. Highly educated women reported the poorest HRQOL. The analysis of variance also indicated a significant variation in HRQOL scores among body mass index categories [F (4,270) = 5.09, P = <.001] and hirsutism status [F (2,272) = 14.222, P =<.001].
CONCLUSIONS: Menstrual irregularity, hirsutism, increased body mass index, educational status, and age are critical in altering HRQOL in PCOS cases. Clinicians should inquire about the HRQOL of patients with severe clinical manifestations and appropriate support must be provided during patient care.
METHODS: This cross-sectional study was carried out in the tertiary care hospital in India. A total of 275 women visiting the same setting and diagnosed with PCOS were included. The participants\' quality of life was studied using a disease-specific HRQOL questionnaire. Information regarding clinical and socio-demographics was collected using the interviewer schedule. For evaluating the predictors of HRQOL in PCOS subjects, analysis of variance and independent t-test was applied. For subgroup analysis, the post hoc (Gabriel) test was applied.
RESULTS: The average total score of HRQOL of the study participants was 125.41 ± 29.1. The lowest weighted mean score was for menstrual problems. Among the socio-demographic variables, age and educational level influenced the HRQOL scores. Highly educated women reported the poorest HRQOL. The analysis of variance also indicated a significant variation in HRQOL scores among body mass index categories [F (4,270) = 5.09, P = <.001] and hirsutism status [F (2,272) = 14.222, P =<.001].
CONCLUSIONS: Menstrual irregularity, hirsutism, increased body mass index, educational status, and age are critical in altering HRQOL in PCOS cases. Clinicians should inquire about the HRQOL of patients with severe clinical manifestations and appropriate support must be provided during patient care.
摘要：
背景：多囊卵巢综合征（PCOS）是一种复杂且异质性的疾病，会影响身体的各种器官。月经不规律,无排卵,PCOS患者面临的许多美容问题危及女性的本质，并可能对其健康相关生活质量（HRQOL）产生有害影响。本研究旨在评估PCOS患者的HRQOL，并确定可能预测HRQOL不良的临床和社会人口统计学因素。
方法：这项横断面研究是在印度的三级保健医院进行的。共有275名访问相同环境并被诊断患有PCOS的妇女被包括在内。使用疾病特异性HRQOL问卷研究参与者的生活质量。使用访谈者时间表收集有关临床和社会人口统计学的信息。为了评估PCOS受试者的HRQOL预测因子，采用方差分析和独立t检验。对于子组分析，事后(加布里埃尔)测试被应用。
结果：研究参与者的HRQOL平均总分为125.41±29.1。最低的加权平均得分是月经问题。在社会人口统计学变量中，年龄和教育水平影响HRQOL得分。受过高等教育的妇女报告了最贫穷的HRQOL。方差分析还表明，在体重指数类别[F（4,270）=5.09，P=<.001]和多毛状态[F（2,272）=14.222，P=<.001]之间，HRQOL得分存在显着差异。
结论：月经不规律，多毛症,身体质量指数增加，教育状况,和年龄是改变PCOS患者HRQOL的关键。临床医生应询问有严重临床表现的患者的HRQOL，并在患者护理期间必须提供适当的支持。
方法：这项横断面研究是在印度的三级保健医院进行的。共有275名访问相同环境并被诊断患有PCOS的妇女被包括在内。使用疾病特异性HRQOL问卷研究参与者的生活质量。使用访谈者时间表收集有关临床和社会人口统计学的信息。为了评估PCOS受试者的HRQOL预测因子，采用方差分析和独立t检验。对于子组分析，事后(加布里埃尔)测试被应用。
结果：研究参与者的HRQOL平均总分为125.41±29.1。最低的加权平均得分是月经问题。在社会人口统计学变量中，年龄和教育水平影响HRQOL得分。受过高等教育的妇女报告了最贫穷的HRQOL。方差分析还表明，在体重指数类别[F（4,270）=5.09，P=<.001]和多毛状态[F（2,272）=14.222，P=<.001]之间，HRQOL得分存在显着差异。
结论：月经不规律，多毛症,身体质量指数增加，教育状况,和年龄是改变PCOS患者HRQOL的关键。临床医生应询问有严重临床表现的患者的HRQOL，并在患者护理期间必须提供适当的支持。
