PDF(Pubmed)
Abstract：
UNASSIGNED: Basal cell carcinoma (BCC) is the most common skin cancer in humans, occurring in more than 50% of Caucasians during their lifetime, with a frequency rate that is continually increasing.
UNASSIGNED: We present a systematic review summarizing the role of transforming growth factor β (TGF-β), cathelicidin, and human β-defensins (HBDs) in the pathogenesis of BCC. The major online databases including PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to extract studies regarding the levels of TGF-β, HBD, and cathelicidin in BCC.
UNASSIGNED: A total of 14 studies met the inclusion criteria and were included in this systematic review. There were 6 studies that included initially established levels of TGF-β in BCCs. A total of 87 BCCs were analysed, and a common result was that the TGF-β levels increase in the BCCs compared to the control groups. Analogously, 2 studies contained numerical data on HBD levels but with a different in methodology. The level of cathelicidin was established in 108 BCCs and was significantly higher in the BCC group than in the control group.
UNASSIGNED: The presented review shows evidence that proteins like TGF-β, HBD, and cathelicidin play a role in developing BCC. Protein levels or their expression are elevated in patients with BCC. Furthermore, a critical review of the literature was presented and discussed, highlighting its shortcomings.
UNASSIGNED: We present a systematic review summarizing the role of transforming growth factor β (TGF-β), cathelicidin, and human β-defensins (HBDs) in the pathogenesis of BCC. The major online databases including PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to extract studies regarding the levels of TGF-β, HBD, and cathelicidin in BCC.
UNASSIGNED: A total of 14 studies met the inclusion criteria and were included in this systematic review. There were 6 studies that included initially established levels of TGF-β in BCCs. A total of 87 BCCs were analysed, and a common result was that the TGF-β levels increase in the BCCs compared to the control groups. Analogously, 2 studies contained numerical data on HBD levels but with a different in methodology. The level of cathelicidin was established in 108 BCCs and was significantly higher in the BCC group than in the control group.
UNASSIGNED: The presented review shows evidence that proteins like TGF-β, HBD, and cathelicidin play a role in developing BCC. Protein levels or their expression are elevated in patients with BCC. Furthermore, a critical review of the literature was presented and discussed, highlighting its shortcomings.
摘要：
■基底细胞癌（BCC）是人类最常见的皮肤癌，发生在50%以上的白种人的一生中，频率不断增加。
■我们对转化生长因子β(TGF-β)的作用进行了系统综述,cathelicidin,和人β-防御素（HBDs）在BCC发病机理中的作用。包括PubMed在内的主要在线数据库，Scopus,Embase,WebofScience,科克伦图书馆,和谷歌学者被搜索来提取关于TGF-β水平的研究，HBD,和BCC中的cathelicidin。
■共有14项研究符合纳入标准，纳入本系统综述。有6项研究包括最初确定的TGF-β在BCC中的水平。共分析了87个BCC，一个共同的结果是，与对照组相比，BCC中的TGF-β水平增加。类似地,2项研究包含HBD水平的数值数据，但方法不同。在108个BCC中建立了cathelicidin的水平，并且在BCC组中明显高于对照组。
■所发表的评论显示，像TGF-β这样的蛋白质，HBD,cathelicidin在BCC的发展中起作用。BCC患者的蛋白质水平或其表达升高。此外，对文献进行了批判性的回顾和讨论，突出其缺点。
■我们对转化生长因子β(TGF-β)的作用进行了系统综述,cathelicidin,和人β-防御素（HBDs）在BCC发病机理中的作用。包括PubMed在内的主要在线数据库，Scopus,Embase,WebofScience,科克伦图书馆,和谷歌学者被搜索来提取关于TGF-β水平的研究，HBD,和BCC中的cathelicidin。
■共有14项研究符合纳入标准，纳入本系统综述。有6项研究包括最初确定的TGF-β在BCC中的水平。共分析了87个BCC，一个共同的结果是，与对照组相比，BCC中的TGF-β水平增加。类似地,2项研究包含HBD水平的数值数据，但方法不同。在108个BCC中建立了cathelicidin的水平，并且在BCC组中明显高于对照组。
■所发表的评论显示，像TGF-β这样的蛋白质，HBD,cathelicidin在BCC的发展中起作用。BCC患者的蛋白质水平或其表达升高。此外，对文献进行了批判性的回顾和讨论，突出其缺点。
