PDF(Pubmed)
Abstract：
UNASSIGNED: Autoimmune encephalitis (AE) is an increasingly recognized neuroinflammatory disease entity in which early detection and treatment leads to the best clinical outcomes. Movement disorders occur in AE but their characteristics are not well defined.
UNASSIGNED: To identify the frequency, classification, and prognostic significance of movement disorders in AE.
UNASSIGNED: We conducted a systematic review and random-effects meta-analysis of movement disorders in cell surface antibody mediated AE. The frequency of any movement disorder as well as the classification of movement disorders in AE serotypes was determined. We looked at adults 18 years and older and included publications that described at least 10 cases. We used the following four electronic databases: Medline (Ovid), EMBASE (Ovid), APA Psychinfo, and Cochrane library.
UNASSIGNED: A total of 1,192 titles and abstracts were reviewed. Thirty-seven studies were included in the final meta-analysis. At least one kind of movement disorder was present in 40% of the entire AE cohort, 53% with anti-NMDA receptor antibodies, 33% with anti-CASPR2 antibodies, 30% with anti-LGI1 antibodies and 13% with anti-GABA receptor antibodies. Dyskinesia was the commonest movement disorder in anti-NMDA antibody mediated AE and faciobrachial dystonic seizures were most frequent in anti-LGI1 antibody mediated AE. Patients with a movement disorder tended to have a higher mortality. The risk of bias in the included studies was mostly moderate or high.
UNASSIGNED: Movement disorders are common in AE and their identification, in conjunction with other clinical and paraclinical features, may facilitate earlier diagnosis. The prognostic implications of movement disorders in AE warrant further dedicated study.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42023386920.
UNASSIGNED: To identify the frequency, classification, and prognostic significance of movement disorders in AE.
UNASSIGNED: We conducted a systematic review and random-effects meta-analysis of movement disorders in cell surface antibody mediated AE. The frequency of any movement disorder as well as the classification of movement disorders in AE serotypes was determined. We looked at adults 18 years and older and included publications that described at least 10 cases. We used the following four electronic databases: Medline (Ovid), EMBASE (Ovid), APA Psychinfo, and Cochrane library.
UNASSIGNED: A total of 1,192 titles and abstracts were reviewed. Thirty-seven studies were included in the final meta-analysis. At least one kind of movement disorder was present in 40% of the entire AE cohort, 53% with anti-NMDA receptor antibodies, 33% with anti-CASPR2 antibodies, 30% with anti-LGI1 antibodies and 13% with anti-GABA receptor antibodies. Dyskinesia was the commonest movement disorder in anti-NMDA antibody mediated AE and faciobrachial dystonic seizures were most frequent in anti-LGI1 antibody mediated AE. Patients with a movement disorder tended to have a higher mortality. The risk of bias in the included studies was mostly moderate or high.
UNASSIGNED: Movement disorders are common in AE and their identification, in conjunction with other clinical and paraclinical features, may facilitate earlier diagnosis. The prognostic implications of movement disorders in AE warrant further dedicated study.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42023386920.
摘要：
自身免疫性脑炎(AE)是一种日益被认可的神经炎性疾病实体,其中早期检测和治疗导致最佳临床结果。运动障碍发生在AE中，但其特征尚未明确。
■要确定频率，分类，运动障碍在AE中的预后意义。
■我们对细胞表面抗体介导的AE中的运动障碍进行了系统综述和随机效应荟萃分析。确定了AE血清型中任何运动障碍的频率以及运动障碍的分类。我们研究了18岁及以上的成年人，并包括描述至少10例病例的出版物。我们使用了以下四个电子数据库：Medline(Ovid)，EMBASE(Ovid),APA心理信息，科克伦图书馆
■共审查了1,192篇标题和摘要。37项研究被纳入最终的荟萃分析。在整个AE队列的40％中至少存在一种运动障碍，53%与抗NMDA受体抗体，33%与抗CASPR2抗体，30%与抗LGI1抗体和13%与抗GABA受体抗体。运动障碍是抗NMDA抗体介导的AE中最常见的运动障碍，而面臂肌张力障碍发作在抗LGI1抗体介导的AE中最常见。运动障碍患者的死亡率往往较高。纳入研究的偏倚风险大多为中等或高。
■运动障碍在AE及其鉴定中很常见，结合其他临床和临床特征，可以促进早期诊断。AE中运动障碍的预后意义值得进一步研究。
■https://www.crd.约克。AC.英国/普华永道/，标识符：CRD42023386920。
■要确定频率，分类，运动障碍在AE中的预后意义。
■我们对细胞表面抗体介导的AE中的运动障碍进行了系统综述和随机效应荟萃分析。确定了AE血清型中任何运动障碍的频率以及运动障碍的分类。我们研究了18岁及以上的成年人，并包括描述至少10例病例的出版物。我们使用了以下四个电子数据库：Medline(Ovid)，EMBASE(Ovid),APA心理信息，科克伦图书馆
■共审查了1,192篇标题和摘要。37项研究被纳入最终的荟萃分析。在整个AE队列的40％中至少存在一种运动障碍，53%与抗NMDA受体抗体，33%与抗CASPR2抗体，30%与抗LGI1抗体和13%与抗GABA受体抗体。运动障碍是抗NMDA抗体介导的AE中最常见的运动障碍，而面臂肌张力障碍发作在抗LGI1抗体介导的AE中最常见。运动障碍患者的死亡率往往较高。纳入研究的偏倚风险大多为中等或高。
■运动障碍在AE及其鉴定中很常见，结合其他临床和临床特征，可以促进早期诊断。AE中运动障碍的预后意义值得进一步研究。
■https://www.crd.约克。AC.英国/普华永道/，标识符：CRD42023386920。
