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Abstract：
UNASSIGNED: The aim of the current study was to identify the expression of P63 and its relation to odontogenic epithelial cell proliferation, severity of the inflammatory infiltrate and size of radicular cysts (RCs).
UNASSIGNED: In this retrospective cross-sectional study, 30 cases of paraffin-embedded RCs were randomly selected from the archive. P63 and Ki-67 expression was assessed by immunohistochemistry.
UNASSIGNED: Epithelial P63 expression was absent in four (13.3%), weak in 10 (33.3%), and moderate in 16 (53.3%) cases. In the connective tissue wall of RC, P63 expression was absent in two (6.7%) cases, weak in 24 (80.0%) cases, and moderate in four (13.3%) cases. Ki-67 was found to be weakly expressed in 12 (40.0%) cases, moderately expressed in 13 (43.3%), and strongly expressed in five (16.7%) cases. No correlation was found between Ki-67 expression in odontogenic epithelium and P63 expression in the odontogenic epithelium (rho = 0.110, p = .563) or fibrous capsule (rho = 0.160, p = .399). Nevertheless, we found a positive correlation between Ki-67 expression in the odontogenic epithelium and the size of the RC (rho = 0.450, p = .013). The inflammatory infiltrate was negatively correlated with P63 expression in the odontogenic epithelium (rho = -0.428, p = .018), and with the size of cysts (rho = -0.728, p < .001).
UNASSIGNED: There is a high expression of P63 throughout the odontogenic epithelium and connective tissue capsule of the RC. P63 expression in the odontogenic epithelium is negatively correlated with the degree of the inflammatory infiltrate but not with epithelial cell proliferation or the size of the cyst.
UNASSIGNED: In this retrospective cross-sectional study, 30 cases of paraffin-embedded RCs were randomly selected from the archive. P63 and Ki-67 expression was assessed by immunohistochemistry.
UNASSIGNED: Epithelial P63 expression was absent in four (13.3%), weak in 10 (33.3%), and moderate in 16 (53.3%) cases. In the connective tissue wall of RC, P63 expression was absent in two (6.7%) cases, weak in 24 (80.0%) cases, and moderate in four (13.3%) cases. Ki-67 was found to be weakly expressed in 12 (40.0%) cases, moderately expressed in 13 (43.3%), and strongly expressed in five (16.7%) cases. No correlation was found between Ki-67 expression in odontogenic epithelium and P63 expression in the odontogenic epithelium (rho = 0.110, p = .563) or fibrous capsule (rho = 0.160, p = .399). Nevertheless, we found a positive correlation between Ki-67 expression in the odontogenic epithelium and the size of the RC (rho = 0.450, p = .013). The inflammatory infiltrate was negatively correlated with P63 expression in the odontogenic epithelium (rho = -0.428, p = .018), and with the size of cysts (rho = -0.728, p < .001).
UNASSIGNED: There is a high expression of P63 throughout the odontogenic epithelium and connective tissue capsule of the RC. P63 expression in the odontogenic epithelium is negatively correlated with the degree of the inflammatory infiltrate but not with epithelial cell proliferation or the size of the cyst.
摘要：
■本研究的目的是确定P63的表达及其与牙源性上皮细胞增殖的关系，炎性浸润的严重程度和根性囊肿（RCs）的大小。
■在这项回顾性横断面研究中，从档案中随机选择30例石蜡包埋的RC。通过免疫组织化学评估P63和Ki-67的表达。
■4例（13.3%）上皮P63表达缺失，弱在10(33.3%)，16例(53.3%)为中度。在RC的结缔组织壁中，2例(6.7%)P63表达缺失,在24例（80.0%）中较弱，4例(13.3%)为中度。发现Ki-67在12例(40.0%)中弱表达,中度表达为13（43.3％），在5例(16.7%)中有强烈表达。牙源性上皮中Ki-67的表达与牙源性上皮（rho=0.110，p=.563）或纤维囊（rho=0.160，p=.399）中P63的表达无相关性。然而，我们发现Ki-67在牙源性上皮中的表达与RC大小呈正相关(rho=0.450,p=0.013).炎症浸润与牙源性上皮中P63的表达呈负相关（rho=-0.428，p=0.018），和囊肿的大小（rho=-0.728，p<.001）。
■P63在整个牙源性上皮和RC的结缔组织包膜中高表达。牙源性上皮中P63的表达与炎症浸润程度呈负相关，但与上皮细胞增殖或囊肿大小无关。
■在这项回顾性横断面研究中，从档案中随机选择30例石蜡包埋的RC。通过免疫组织化学评估P63和Ki-67的表达。
■4例（13.3%）上皮P63表达缺失，弱在10(33.3%)，16例(53.3%)为中度。在RC的结缔组织壁中，2例(6.7%)P63表达缺失,在24例（80.0%）中较弱，4例(13.3%)为中度。发现Ki-67在12例(40.0%)中弱表达,中度表达为13（43.3％），在5例(16.7%)中有强烈表达。牙源性上皮中Ki-67的表达与牙源性上皮（rho=0.110，p=.563）或纤维囊（rho=0.160，p=.399）中P63的表达无相关性。然而，我们发现Ki-67在牙源性上皮中的表达与RC大小呈正相关(rho=0.450,p=0.013).炎症浸润与牙源性上皮中P63的表达呈负相关（rho=-0.428，p=0.018），和囊肿的大小（rho=-0.728，p<.001）。
■P63在整个牙源性上皮和RC的结缔组织包膜中高表达。牙源性上皮中P63的表达与炎症浸润程度呈负相关，但与上皮细胞增殖或囊肿大小无关。
