PDF(Pubmed)
Abstract：
BACKGROUND: Cryptococcal meningitis (CM) is an inflammatory mycosis of the central nervous system caused by meninge infection or brain parenchyma with Cryptococcus species. It is associated with high morbidity and mortality, and patients with acquired immune deficiency syndrome are particularly susceptible. There have been increasing reports of CM in HIV-negative patients in China over the last few years.
METHODS: A 31-year-old healthy Chinese male presented with fever and gradually developed headache, projectile vomiting, and other manifestations that were later confirmed as Cryptococcus gattii meningoencephalitis. However, multiple disease changes occurred during the course of treatment, and the regimen was accordingly modified after the diagnosis of post-infectious inflammatory response syndrome (PIIRS). The patient eventually recovered.
CONCLUSIONS: There has been a growing trend in the incidence of C. gattii meningoencephalitis in HIV-negative patients. It shows rapid onset and severe prognosis. This case report can provide a reference to treat PIIRS following CM in HIV-negative patients.
METHODS: A 31-year-old healthy Chinese male presented with fever and gradually developed headache, projectile vomiting, and other manifestations that were later confirmed as Cryptococcus gattii meningoencephalitis. However, multiple disease changes occurred during the course of treatment, and the regimen was accordingly modified after the diagnosis of post-infectious inflammatory response syndrome (PIIRS). The patient eventually recovered.
CONCLUSIONS: There has been a growing trend in the incidence of C. gattii meningoencephalitis in HIV-negative patients. It shows rapid onset and severe prognosis. This case report can provide a reference to treat PIIRS following CM in HIV-negative patients.
摘要：
背景：隐球菌性脑膜炎（CM）是由脑膜感染或脑实质与隐球菌属引起的中枢神经系统的炎性真菌病。它与高发病率和死亡率有关，获得性免疫缺陷综合征患者尤其易感。在过去的几年中，中国HIV阴性患者中CM的报道越来越多。
方法:一名31岁健康的中国男性,出现发热,逐渐出现头痛,抛射性呕吐,和其他后来被证实为加蒂隐球菌脑膜脑炎的表现。然而,在治疗过程中发生多种疾病变化，并在诊断感染后炎症反应综合征(PIIRS)后对治疗方案进行相应修改。患者最终康复。
结论：在HIV阴性患者中，加替氏杆菌脑膜脑炎的发病率呈增长趋势。它显示快速发病和严重预后。该病例报告可为HIV阴性患者CM后PIIRS的治疗提供参考。
方法:一名31岁健康的中国男性,出现发热,逐渐出现头痛,抛射性呕吐,和其他后来被证实为加蒂隐球菌脑膜脑炎的表现。然而,在治疗过程中发生多种疾病变化，并在诊断感染后炎症反应综合征(PIIRS)后对治疗方案进行相应修改。患者最终康复。
结论：在HIV阴性患者中，加替氏杆菌脑膜脑炎的发病率呈增长趋势。它显示快速发病和严重预后。该病例报告可为HIV阴性患者CM后PIIRS的治疗提供参考。
