Abstract：
Lymph node metastasis has been shown to positively associated with the prognosis of many cancers. However, in clinical treatment, lymphadenectomy is not always successful, suggesting that immune cells in the tumor and sentinel lymph nodes still play a pivotal role in tumor immunosuppression. Recent studies had shown that tumors can tolerate immune cells through multiple strategies, including tumor-induced macrophage reprogramming, T cells inactivation, production of B cells pathogenic antibodies and activation of regulatory T cells to promote tumor colonization, growth, and metastasis in lymph nodes. We reviewed the bidirectional effect of immune cells on anti-tumor or promotion of cancer cell metastasis during lymph node metastasis, and the mechanisms by which malignant cancer cells modify immune cells to create a more favorable environment for the growth and survival of cancer cells. Research and treatment strategies focusing on the immune system in lymph nodes and potential immune targets in lymph node metastasis were also be discussed.
摘要：
淋巴结转移已被证明与许多癌症的预后呈正相关。然而,在临床治疗中,淋巴结清扫术并不总是成功的，提示肿瘤和前哨淋巴结中的免疫细胞在肿瘤免疫抑制中仍起着关键作用。最近的研究表明，肿瘤可以通过多种策略耐受免疫细胞，包括肿瘤诱导的巨噬细胞重编程，T细胞失活,B细胞致病性抗体的产生和调节性T细胞的激活，以促进肿瘤定植，增长,淋巴结转移。我们综述了免疫细胞在淋巴结转移过程中对抗肿瘤或促进癌细胞转移的双向作用。以及恶性癌细胞修饰免疫细胞的机制，为癌细胞的生长和存活创造更有利的环境。还讨论了针对淋巴结中免疫系统的研究和治疗策略以及淋巴结转移中潜在的免疫靶标。
