Abstract：
Cancer is one of the leading causes of mortality and morbidity worldwide, affecting millions of people physically and financially every year. Over time, many anticancer treatments have been proposed and studied, including synthetic compound consumption, surgical procedures, or grueling chemotherapy. Although these treatments have improved the daily life quality of patients and increased their survival rate and life expectancy, they have also shown significant drawbacks, including staggering costs, multiple side effects, and difficulty in compliance and adherence to treatment. Therefore, natural compounds have been considered a possible key to overcoming these problems in recent years, and thorough research has been done to assess their effectiveness. In these studies, scientists have discovered a meaningful interaction between several natural materials and signal transducer and activator of transcription 3 molecules. STAT3 is a transcriptional protein that is vital for cell growth and survival. Mechanistic studies have established that activated STAT3 can increase cancer cell proliferation and invasion while reducing anticancer immunity. Thus, inhibiting STAT3 signaling by natural compounds has become one of the favorite research topics and an attractive target for developing novel cancer treatments. In the present article, we intend to comprehensively review the latest knowledge about the effects of various organic compounds on inhibiting the STAT3 signaling pathway to cure different cancer diseases.
摘要：
癌症是全球死亡率和发病率的主要原因之一，每年影响数百万人的身体和经济。随着时间的推移,已经提出和研究了许多抗癌治疗方法，包括合成化合物的消费，外科手术,或者艰苦的化疗。尽管这些治疗方法改善了患者的日常生活质量，提高了患者的生存率和预期寿命，它们也显示出明显的缺点，包括惊人的成本，多种副作用,以及依从性和坚持治疗的困难。因此,近年来，天然化合物被认为是克服这些问题的可能关键，并进行了深入的研究以评估其有效性。在这些研究中,科学家发现了几种天然物质与信号转导和转录激活因子3分子之间有意义的相互作用。STAT3是对细胞生长和存活至关重要的转录蛋白。机制研究已经确定激活的STAT3可以增加癌细胞增殖和侵袭，同时降低抗癌免疫力。因此，通过天然化合物抑制STAT3信号传导已成为最受欢迎的研究课题之一，也是开发新癌症治疗的有吸引力的目标。在本文中,我们打算全面回顾有关各种有机化合物抑制STAT3信号通路治疗不同癌症疾病的最新知识.
