Abstract：
Platelet-rich plasma (PRP) contains a variety of growth factors and has been widely used in maxillofacial surgery, orthopedics, plastic surgery, ophthalmology, and other fields. In recent years, with the increasing morbidity of androgenetic alopecia (AGA), the use of PRP has also increased. The objective of this article was to evaluate the efficacy and safety of PRP for AGA. We searched PubMed, Embase, Web of Science, and Cochrane Library, covering the databases from their earliest records until March 2022. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to explore the effects of PRP for hair density, hair count, and hair diameter in AGA. Nine trials involving 238 patients were included. The meta-analysis showed that PRP for AGA increased hair density at 3 and 6 months with statistically significant differences compared with the placebo (P < .05). PRP also increased hair count and hair diameter compared with the baseline, but there was no significant difference compared with the placebo (P > .05). Two of the 7 studies reported adverse reactions. No serious adverse reactions were found. In conclusion, PRP is an effective and safe treatment for increasing the hair density in AGA. Trial registration: The systematic review was registered with PROSPERO (CRD42022362432).
摘要：
富血小板血浆(PRP)含有多种生长因子,已广泛应用于颌面外科,骨科,整形手术,眼科,和其他领域。近年来,随着雄激素性脱发(AGA)发病率的增加，PRP的使用也有所增加。本文的目的是评估PRP用于AGA的有效性和安全性。我们搜索了PubMed,Embase,WebofScience,和Cochrane图书馆,从最早的记录到2022年3月覆盖数据库。我们对随机对照试验（RCTs）进行了系统评价和荟萃分析，以探讨PRP对头发密度的影响。头发计数,和AGA中的头发直径。纳入了涉及238名患者的9项试验。荟萃分析显示，与安慰剂相比，PRP在3个月和6个月时增加了头发密度（P<0.05）。与基线相比，PRP还增加了头发数量和头发直径，但与安慰剂组相比无显著性差异(P>.05)。7项研究中有2项报告了不良反应。未发现严重不良反应。总之,PRP是增加AGA中头发密度的有效且安全的治疗方法。试验注册：系统评价在PROSPERO（CRD42022362432）注册。
