Abstract：
Electrospray ionization (ESI) is one of the most widely used ionization techniques, and its simplification can benefit many interested users. In this study, sample introduction by capillary action was studied and used to develop a simple ESI source called capillary self-aspirating electrospray ionization (CSESI). A conventional CSESI source requires only a common capillary of appropriate diameter in addition to the support of high voltage (HV). No pumps and sample loading is needed because the solution can spontaneously climb across the capillary by capillary action. With the proper modification of the glass capillary, the operation of CSESI can be further simplified and efficient. Specifically, cold plasma processing of the capillary creates a more hydrophilic surface that can facilitate sample introduction. Moreover, sputtering a thin platinum layer on the capillary tip makes the application of HV more convenient, and it also eliminates the influence of air bubbles in the capillary to ensure a sustained and stable electrospray. Overall, CSESI exhibits multiple desirable features such as simple structure, self-aspiration ability, low sample consumption, and inherent physical filtration capability. Apart from the routine ESI-MS analysis, it has also been applied in real-time monitoring of the oxidative dimerization of 8-methyl-1,2,3,4-tetrahydroquinoline, as well as direct analysis of muddy soil solutions without pretreatment.
摘要：
电喷雾电离(ESI)是目前应用最广泛的电离技术之一,它的简化可以使许多感兴趣的用户受益。在这项研究中,研究了通过毛细管作用引入的样品，并用于开发一种简单的ESI源，称为毛细管自吸气电喷雾电离（CSESI）。除了高电压(HV)的支持之外,常规的CSESI源仅需要具有适当直径的共用毛细管。不需要泵和样品装载,因为溶液可以通过毛细管作用自发地爬过毛细管。随着玻璃毛细管的适当修改，CSESI的操作可以进一步简化和高效。具体来说,毛细管的冷等离子体处理产生更亲水的表面，可以促进样品的引入。此外，在毛细管尖端溅射薄铂层使HV的应用更加方便，它还消除了毛细管中气泡的影响，以确保持续稳定的电喷雾。总的来说,CSESI表现出多种理想的特征，如结构简单，自我渴望能力，低样品消耗，和固有的物理过滤能力。除了常规的ESI-MS分析，它还被用于实时监测8-甲基-1,2,3,4-四氢喹啉的氧化二聚，以及直接分析不预处理的泥质土壤溶液。
