PDF(Pubmed)
Abstract：
UNASSIGNED: This retrospective study analyzed the prognostic value of preoperative prealbumin (PAB) levels in patients with unresectable hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolisation (TACE).
UNASSIGNED: Four hundred and two patients diagnosed with unresectable HCC were included in this retrospective study. All patients underwent their first TACE procedure. Based on PAB levels before the first TACE, 402 patients were classified as having low PAB levels and high PAB levels. Potential confounding factors between the two groups were eliminated using. Propensity Score Matching (PSM) analysis. The time to progression (TTP) and overall survival (OS) of the two groups were compared using Kaplan-Meier curves before and after PSM. Risk factors for poor prognosis were determined using univariate and multivariate Cox proportional hazards models.
UNASSIGNED: Before PSM, the high PAB level group had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.0001). After PSM, the high PAB level group still had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.05). After PSM, low PAB level was found to be an independent predictor of shorter OS (HR = 0.656; 95% CI:0.448-0.961; P = 0.03). The subgroup analysis before PSM showed that low PAB levels increased the risk of poor prognosis in most subgroups.
UNASSIGNED: Low preoperative PAB levels are associated with poor prognosis in patients with unresectable HCC after TACE.
UNASSIGNED: Four hundred and two patients diagnosed with unresectable HCC were included in this retrospective study. All patients underwent their first TACE procedure. Based on PAB levels before the first TACE, 402 patients were classified as having low PAB levels and high PAB levels. Potential confounding factors between the two groups were eliminated using. Propensity Score Matching (PSM) analysis. The time to progression (TTP) and overall survival (OS) of the two groups were compared using Kaplan-Meier curves before and after PSM. Risk factors for poor prognosis were determined using univariate and multivariate Cox proportional hazards models.
UNASSIGNED: Before PSM, the high PAB level group had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.0001). After PSM, the high PAB level group still had a significantly longer median TTP and OS than the low PAB level group (all P values < 0.05). After PSM, low PAB level was found to be an independent predictor of shorter OS (HR = 0.656; 95% CI:0.448-0.961; P = 0.03). The subgroup analysis before PSM showed that low PAB levels increased the risk of poor prognosis in most subgroups.
UNASSIGNED: Low preoperative PAB levels are associated with poor prognosis in patients with unresectable HCC after TACE.
摘要：
■这项回顾性研究分析了经肝动脉化疗栓塞术（TACE）后无法切除的肝细胞癌（HCC）患者术前前白蛋白（PAB）水平的预后价值。
■本回顾性研究包括四百零二例诊断为不可切除的HCC的患者。所有患者均接受了首次TACE手术。基于第一次TACE之前的PAB水平，402名患者被分类为具有低PAB水平和高PAB水平。使用消除两组之间潜在的混杂因素。倾向得分匹配(PSM)分析。采用Kaplan-Meier曲线比较两组患者PSM前后的进展时间(TTP)和总生存期(OS)。使用单变量和多变量Cox比例风险模型确定不良预后的危险因素。
■PSM之前，高PAB水平组的中位TTP和OS显著长于低PAB水平组(所有P值<0.0001).PSM之后,高PAB水平组的中位TTP和OS仍明显长于低PAB水平组(所有P值<0.05).PSM之后,发现低PAB水平是OS较短的独立预测因子(HR=0.656;95%CI:0.448-0.961;P=0.03).PSM之前的亚组分析显示，低PAB水平增加了大多数亚组预后不良的风险。
■术前PAB水平低与TACE术后无法切除的HCC患者预后不良相关。
■本回顾性研究包括四百零二例诊断为不可切除的HCC的患者。所有患者均接受了首次TACE手术。基于第一次TACE之前的PAB水平，402名患者被分类为具有低PAB水平和高PAB水平。使用消除两组之间潜在的混杂因素。倾向得分匹配(PSM)分析。采用Kaplan-Meier曲线比较两组患者PSM前后的进展时间(TTP)和总生存期(OS)。使用单变量和多变量Cox比例风险模型确定不良预后的危险因素。
■PSM之前，高PAB水平组的中位TTP和OS显著长于低PAB水平组(所有P值<0.0001).PSM之后,高PAB水平组的中位TTP和OS仍明显长于低PAB水平组(所有P值<0.05).PSM之后,发现低PAB水平是OS较短的独立预测因子(HR=0.656;95%CI:0.448-0.961;P=0.03).PSM之前的亚组分析显示，低PAB水平增加了大多数亚组预后不良的风险。
■术前PAB水平低与TACE术后无法切除的HCC患者预后不良相关。
