METHODS: Retrospective case series.
METHODS: Two hundred forty-three eyes of 243 AMD patients affected by type 1 and type 2 macular neovascularization (MNV).
METHODS: We analyzed data considering MNV onset, 1-year, and 2-year timepoints. Optical coherence tomography images were used to classify MNV types, distinguish different types of fluids and assess IRF localization within retinal layers. A subcohort of eyes were also analyzed by OCT angiography.
METHODS: The association between IRF cyst localization and both visual outcome and onset of outer retinal atrophy at 2-year follow-up.
RESULTS: Macular neovascularizations were distributed as type 1 (69%) and type 2 (31%). The mean number of intravitreal injections was 7 ± 2 at 1-year follow-up and 5 ± 2 at 2-year follow-up. Baseline best-corrected visual acuity was 0.4 ± 0.3 logarithm of the minimum angle of resolution, improving to 0.3 ± 0.4 at 2-year follow-up (P < 0.01). Outer retinal atrophy occurred in 24% of cases at 1 year and 39% of cases at 2-year follow-up. Intraretinal fluid localizations at the level of IPL-INL and OPL-ONL at baseline were associated with the worst functional and anatomical outcome. Moreover, the presence of IRF at baseline was associated with greater impairment of the intraretinal vascular network.
CONCLUSIONS: The localization of IRF at the level of IPL-INL and OPL-ONL retinal layers represents a negative prognostic biomarker for the morphologic and functional outcomes of neovascular AMD.
BACKGROUND: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
方法:回顾性病例系列。
方法:243眼受1型和2型黄斑新生血管(MNV)影响的AMD患者。
方法:我们分析了考虑MNV发作的数据,1年和2年时间点。光学相干断层扫描(OCT)图像用于对MNV类型进行分类,区分不同类型的液体并评估视网膜层中的IRF定位。还通过OCT血管造影术分析了一个子群的眼睛。
方法:在2年随访时,IRF囊肿定位与视觉结果和外部视网膜萎缩发病之间的关联。
结果:MNV分布为1型(69%)和2型(31%)。玻璃体内注射的平均次数在1年为7±2,在2年随访为5±2。基线BCVA为0.4±0.3LogMAR,2年随访时改善至0.3±0.4(p<0.01)。24%的病例在1年发生外视网膜萎缩,39%的病例在2年随访。在基线时IPL-INL和OPL-ONL水平的IRF定位与最差的功能和解剖学结果相关。此外,基线时IRF的存在与视网膜内血管网的更大损害相关.
结论:IRF在IPL-INL和OPL-ONL视网膜层水平的定位代表新生血管性AMD形态和功能结局的阴性预后生物标志物。