Abstract：
UNASSIGNED: Recent studies have suggested a potential causal association between Interleukins (ILs) and Colorectal Cancer (CRC), and thus, it is important to examine the causal relationship between them using a Mendelian randomization (MR) approach.
UNASSIGNED: The instrumental variables were extracted for IL-1ra, IL-6, IL-6ra, IL-8, IL-16, IL-18, IL-27 from genome-wide association studies of European ancestry. Summary statistics of CRC were also retrieved. An inverse variance-weighted MR approach was implemented as the primary method to compute overall effects from multiple instruments. Additional MR approaches and sensitivity and heterogeneity pleiotropy analyses were also conducted respectively.
UNASSIGNED: Our analysis suggested a causal effect between an increase of IL-8 and a reduced risk of CRC (odds ratio 0.65; 95% confidence interval, 0.43-0.98; p = 0.041) and did not provide evidence for causal effects of IL-1ra, IL-6, IL-6ra, IL-16, IL-18, IL-27. Sensitivity analyses suggested the robustness of MR results and that they were unlikely to be affected by unbalanced pleiotropy or significant heterogeneity.
UNASSIGNED: This study investigated the role of ILs in the development of CRC and we found a causal effect between an increase of IL-8 and a reduced risk of CRC but not found evidence for causal effects of IL-1ra, IL-6, IL-6ra, IL-16, IL-18, IL-27. Sensitivity analyses suggested the robustness of MR results and that they were unlikely to be affected by unbalanced pleiotropy or significant heterogeneity.
UNASSIGNED: The instrumental variables were extracted for IL-1ra, IL-6, IL-6ra, IL-8, IL-16, IL-18, IL-27 from genome-wide association studies of European ancestry. Summary statistics of CRC were also retrieved. An inverse variance-weighted MR approach was implemented as the primary method to compute overall effects from multiple instruments. Additional MR approaches and sensitivity and heterogeneity pleiotropy analyses were also conducted respectively.
UNASSIGNED: Our analysis suggested a causal effect between an increase of IL-8 and a reduced risk of CRC (odds ratio 0.65; 95% confidence interval, 0.43-0.98; p = 0.041) and did not provide evidence for causal effects of IL-1ra, IL-6, IL-6ra, IL-16, IL-18, IL-27. Sensitivity analyses suggested the robustness of MR results and that they were unlikely to be affected by unbalanced pleiotropy or significant heterogeneity.
UNASSIGNED: This study investigated the role of ILs in the development of CRC and we found a causal effect between an increase of IL-8 and a reduced risk of CRC but not found evidence for causal effects of IL-1ra, IL-6, IL-6ra, IL-16, IL-18, IL-27. Sensitivity analyses suggested the robustness of MR results and that they were unlikely to be affected by unbalanced pleiotropy or significant heterogeneity.
摘要：
■最近的研究表明，白细胞介素（IL）与结直肠癌（CRC）之间存在潜在的因果关系。因此，使用孟德尔随机化(MR)方法检查两者之间的因果关系非常重要.
■提取IL-1ra的工具变量，IL-6,IL-6ra,IL-8，IL-16，IL-18，IL-27来自欧洲血统的全基因组关联研究。还检索了CRC的汇总统计。采用逆方差加权MR方法作为计算多种仪器整体效果的主要方法。还分别进行了其他MR方法以及敏感性和异质性多效性分析。
■我们的分析表明，IL-8增加与CRC风险降低之间存在因果关系（比值比0.65；95％置信区间，0.43-0.98；p=0.041)，并且没有提供IL-1ra因果效应的证据，IL-6,IL-6ra,IL-16、IL-18、IL-27。敏感性分析表明MR结果的鲁棒性，并且它们不太可能受到不平衡的多效性或显着的异质性的影响。
■这项研究调查了IL-8在CRC发展中的作用，我们发现了IL-8增加和CRC风险降低之间的因果关系，但没有发现IL-1ra因果关系的证据。IL-6,IL-6ra,IL-16、IL-18、IL-27。敏感性分析表明MR结果的鲁棒性，并且它们不太可能受到不平衡的多效性或显着的异质性的影响。
■提取IL-1ra的工具变量，IL-6,IL-6ra,IL-8，IL-16，IL-18，IL-27来自欧洲血统的全基因组关联研究。还检索了CRC的汇总统计。采用逆方差加权MR方法作为计算多种仪器整体效果的主要方法。还分别进行了其他MR方法以及敏感性和异质性多效性分析。
■我们的分析表明，IL-8增加与CRC风险降低之间存在因果关系（比值比0.65；95％置信区间，0.43-0.98；p=0.041)，并且没有提供IL-1ra因果效应的证据，IL-6,IL-6ra,IL-16、IL-18、IL-27。敏感性分析表明MR结果的鲁棒性，并且它们不太可能受到不平衡的多效性或显着的异质性的影响。
■这项研究调查了IL-8在CRC发展中的作用，我们发现了IL-8增加和CRC风险降低之间的因果关系，但没有发现IL-1ra因果关系的证据。IL-6,IL-6ra,IL-16、IL-18、IL-27。敏感性分析表明MR结果的鲁棒性，并且它们不太可能受到不平衡的多效性或显着的异质性的影响。
