PDF(Pubmed)
Abstract：
UNASSIGNED: Asian Indians are at higher risk of cardiometabolic disease compared to other ethnic groups, and the age of onset is typically younger. Cardiac structure and function are poorly characterized in this ethnic group. In this study, we describe image-acquisition methods and the reproducibility of measurements and detailed echocardiography characteristics in two large Indian population-based cohorts (the New Delhi and Vellore Birth Cohorts) from India.
UNASSIGNED: The IndEcho study captured transthoracic echocardiographic measurements of cardiac structure and function from 2,322 men and women aged 43-50 years. M-mode measurements in the parasternal long axis (PLAX) and 2-dimensional (2D) short axis recordings at the mitral valve, mid-papillary and apical level were recorded. Apical 2D recordings of two- three- and four-chamber (2C, 3C and 4C) views and Doppler images (colour, pulsed and continuous) were recorded in cine-loop format. Left ventricular (LV) mass, LV hypertrophy, and indices of LV systolic and diastolic function were derived.
UNASSIGNED: Echocardiographic measurements showed good/excellent technical reproducibility. Hetero-geneity across sites, sex and rural/urban differences in cardiac structure and function were observed. Overall, this cohort of South Asian Indians had smaller LV mass and normal systolic and diastolic function when compared with published data on other Asian Indians and the West, (LV mass indexed for body surface area: Delhi men: 68 g/m2, women 63.9; Vellore men: 65.8, women 61.6) but were within ethnic-specific reference ranges. The higher prevalence of obesity, diabetes and hypertension is reflected by the higher proportion of LV remodelling and lesser hypertrophy.
UNASSIGNED: Our study adds to scarce population-based echocardiographic data for mid-life Asian Indians. Compared to published literature on other ethnic groups, the Asian Indian heart is characterised by smaller cardiac dimensions and normal range systolic and diastolic function on a background of a high prevalence of hypertension, diabetes and cardiac disease at a relatively young age. This data will form the basis for further analyses of lifecourse, metabolic and body composition predictors of cardiac structure and function, and echocardiographic predictors of future mortality.
UNASSIGNED: 13432279.
UNASSIGNED: The IndEcho study captured transthoracic echocardiographic measurements of cardiac structure and function from 2,322 men and women aged 43-50 years. M-mode measurements in the parasternal long axis (PLAX) and 2-dimensional (2D) short axis recordings at the mitral valve, mid-papillary and apical level were recorded. Apical 2D recordings of two- three- and four-chamber (2C, 3C and 4C) views and Doppler images (colour, pulsed and continuous) were recorded in cine-loop format. Left ventricular (LV) mass, LV hypertrophy, and indices of LV systolic and diastolic function were derived.
UNASSIGNED: Echocardiographic measurements showed good/excellent technical reproducibility. Hetero-geneity across sites, sex and rural/urban differences in cardiac structure and function were observed. Overall, this cohort of South Asian Indians had smaller LV mass and normal systolic and diastolic function when compared with published data on other Asian Indians and the West, (LV mass indexed for body surface area: Delhi men: 68 g/m2, women 63.9; Vellore men: 65.8, women 61.6) but were within ethnic-specific reference ranges. The higher prevalence of obesity, diabetes and hypertension is reflected by the higher proportion of LV remodelling and lesser hypertrophy.
UNASSIGNED: Our study adds to scarce population-based echocardiographic data for mid-life Asian Indians. Compared to published literature on other ethnic groups, the Asian Indian heart is characterised by smaller cardiac dimensions and normal range systolic and diastolic function on a background of a high prevalence of hypertension, diabetes and cardiac disease at a relatively young age. This data will form the basis for further analyses of lifecourse, metabolic and body composition predictors of cardiac structure and function, and echocardiographic predictors of future mortality.
UNASSIGNED: 13432279.
摘要：
■与其他种族相比，亚洲印第安人患心脏代谢疾病的风险更高，发病年龄通常较年轻。心脏结构和功能在这个种族中的特征较差。在这项研究中,我们描述了来自印度的两个大型印度人群队列(新德里和Vellore出生队列)的图像采集方法和测量结果的可重复性以及详细的超声心动图特征.
■IndEcho研究捕获了2322名年龄在43-50岁的男性和女性的心脏结构和功能的经胸超声心动图测量结果。M型测量在胸骨旁长轴（PLAX）和2维（2D）短轴记录在二尖瓣，记录中乳头状和根尖水平。两室和四室的心尖2D记录(2C，3C和4C)视图和多普勒图像(彩色，脉冲和连续）以电影循环格式记录。左心室(LV)质量,左心室肥大,并得出LV收缩和舒张功能指标。
■超声心动图测量显示出良好/优异的技术再现性。跨站点的异质性，观察到心脏结构和功能的性别和城乡差异。总的来说,与其他亚洲印第安人和西方国家公布的数据相比，南亚印第安人的左心室质量较小，收缩和舒张功能正常。（左心室体表面积指数：德里男性：68g/m2，女性63.9；Vellore男性：65.8，女性61.6），但在特定种族的参考范围内。肥胖的患病率越高，糖尿病和高血压反映在左心室重塑比例较高和肥大较少。
■我们的研究增加了针对中年亚裔印度人的基于人群的超声心动图数据。与其他种族的公开文献相比，在高血压患病率较高的背景下，亚洲印度心脏的特征是心脏尺寸较小，收缩和舒张功能范围正常。在相对年轻的时候患有糖尿病和心脏病。这些数据将成为进一步分析生命周期的基础，心脏结构和功能的代谢和身体成分预测因子，和超声心动图预测未来死亡率。
■13432279。
■IndEcho研究捕获了2322名年龄在43-50岁的男性和女性的心脏结构和功能的经胸超声心动图测量结果。M型测量在胸骨旁长轴（PLAX）和2维（2D）短轴记录在二尖瓣，记录中乳头状和根尖水平。两室和四室的心尖2D记录(2C，3C和4C)视图和多普勒图像(彩色，脉冲和连续）以电影循环格式记录。左心室(LV)质量,左心室肥大,并得出LV收缩和舒张功能指标。
■超声心动图测量显示出良好/优异的技术再现性。跨站点的异质性，观察到心脏结构和功能的性别和城乡差异。总的来说,与其他亚洲印第安人和西方国家公布的数据相比，南亚印第安人的左心室质量较小，收缩和舒张功能正常。（左心室体表面积指数：德里男性：68g/m2，女性63.9；Vellore男性：65.8，女性61.6），但在特定种族的参考范围内。肥胖的患病率越高，糖尿病和高血压反映在左心室重塑比例较高和肥大较少。
■我们的研究增加了针对中年亚裔印度人的基于人群的超声心动图数据。与其他种族的公开文献相比，在高血压患病率较高的背景下，亚洲印度心脏的特征是心脏尺寸较小，收缩和舒张功能范围正常。在相对年轻的时候患有糖尿病和心脏病。这些数据将成为进一步分析生命周期的基础，心脏结构和功能的代谢和身体成分预测因子，和超声心动图预测未来死亡率。
■13432279。
