PDF(Pubmed)
Abstract：
UNASSIGNED: Chest Computerized Tomography has been widely used in COVID patients\' assessment. Hence the question arises as to whether there is any correlation between the Ct value and findings on Chest CT scan or clinical presentation of the patient. We wanted to test the hypothesis of whether low Ct values (≤30) in RT-PCR were associated with a high mortality rate, CT scan findings, or with comorbidities such as immunosuppression and lung disease.
UNASSIGNED: The radiographic records and RT-PCR Ct values of 371 COVID patents diagnosed at the American University of Beirut Medical Center were reviewed.
UNASSIGNED: We found out that the sensitivity of chest CT scan compared to RT-PCR, the gold standard, turned out to be 74% (95% CI 69-79%). Specificity, on the other hand was 33% (95% CI 16-55%). The positive predictive value of CT was 94% (95% CI 91-97%) and the negative predictive value was 8% (95% CI 4-16%). low Ct values in RT-PCR were not associated with a higher mortality rate (p-value = 0.416). There was no significant positive association between low Ct value and suspicious CT scan findings (typical and indeterminate for COVID-19), with a p-value of 0.078. There was also no significant association between low Ct value and immunosuppression (p-value = 0.511), or lung disease (p-value =0.06). CT scan findings whether suspicious or not for COVID-19 infection, were not shown to be significantly associated with respiratory symptoms of any kind.No association was found between a history of lung disease, immunosuppression and suspicious CT scan findings for COVID-19.
UNASSIGNED: As long as this pandemic exists, nucleic acid testing was and remains the gold standard of COVID-19 diagnosis worldwide and in our community as it has a superior diagnostic accuracy to CT scan and higher sensitivity (94% vs 74%).
UNASSIGNED: The radiographic records and RT-PCR Ct values of 371 COVID patents diagnosed at the American University of Beirut Medical Center were reviewed.
UNASSIGNED: We found out that the sensitivity of chest CT scan compared to RT-PCR, the gold standard, turned out to be 74% (95% CI 69-79%). Specificity, on the other hand was 33% (95% CI 16-55%). The positive predictive value of CT was 94% (95% CI 91-97%) and the negative predictive value was 8% (95% CI 4-16%). low Ct values in RT-PCR were not associated with a higher mortality rate (p-value = 0.416). There was no significant positive association between low Ct value and suspicious CT scan findings (typical and indeterminate for COVID-19), with a p-value of 0.078. There was also no significant association between low Ct value and immunosuppression (p-value = 0.511), or lung disease (p-value =0.06). CT scan findings whether suspicious or not for COVID-19 infection, were not shown to be significantly associated with respiratory symptoms of any kind.No association was found between a history of lung disease, immunosuppression and suspicious CT scan findings for COVID-19.
UNASSIGNED: As long as this pandemic exists, nucleic acid testing was and remains the gold standard of COVID-19 diagnosis worldwide and in our community as it has a superior diagnostic accuracy to CT scan and higher sensitivity (94% vs 74%).
摘要：
■胸部计算机断层扫描已广泛应用于COVID患者的评估。因此，出现了Ct值与胸部CT扫描或患者临床表现之间是否存在任何相关性的问题。我们想检验RT-PCR中的低Ct值（≤30）是否与高死亡率相关的假设。CT扫描结果,或伴有免疫抑制和肺部疾病等合并症。
■回顾了在贝鲁特美国大学医学中心诊断的371项COVID专利的影像学记录和RT-PCRCt值。
■我们发现胸部CT扫描的敏感性与RT-PCR相比，黄金标准,结果为74%（95%CI69-79%）。特异性,另一方面为33%（95%CI16-55%）。CT的阳性预测值为94％（95％CI91-97％），阴性预测值为8％（95％CI4-16％）。RT-PCR的低Ct值与较高的死亡率无关(p值=0.416).低Ct值与可疑CT扫描结果(COVID-19典型且不确定)之间没有显著正相关，p值为0.078。低Ct值与免疫抑制之间也没有显着关联（p值=0.511），或肺部疾病（p值=0.06）。CT扫描发现是否怀疑COVID-19感染，未显示与任何类型的呼吸道症状显着相关。肺部疾病史之间没有发现关联，COVID-19的免疫抑制和可疑CT扫描结果。
■只要这种流行病存在，核酸检测一直是并且仍然是世界范围内和我们社区COVID-19诊断的金标准，因为它具有优于CT扫描的诊断准确性和更高的灵敏度(94%对74%)。
■回顾了在贝鲁特美国大学医学中心诊断的371项COVID专利的影像学记录和RT-PCRCt值。
■我们发现胸部CT扫描的敏感性与RT-PCR相比，黄金标准,结果为74%（95%CI69-79%）。特异性,另一方面为33%（95%CI16-55%）。CT的阳性预测值为94％（95％CI91-97％），阴性预测值为8％（95％CI4-16％）。RT-PCR的低Ct值与较高的死亡率无关(p值=0.416).低Ct值与可疑CT扫描结果(COVID-19典型且不确定)之间没有显著正相关，p值为0.078。低Ct值与免疫抑制之间也没有显着关联（p值=0.511），或肺部疾病（p值=0.06）。CT扫描发现是否怀疑COVID-19感染，未显示与任何类型的呼吸道症状显着相关。肺部疾病史之间没有发现关联，COVID-19的免疫抑制和可疑CT扫描结果。
■只要这种流行病存在，核酸检测一直是并且仍然是世界范围内和我们社区COVID-19诊断的金标准，因为它具有优于CT扫描的诊断准确性和更高的灵敏度(94%对74%)。
