PDF(Pubmed)
Abstract：
UNASSIGNED: Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.
UNASSIGNED: This was a double-blinded randomized clinical trial performed on 125 patients with functional abdominal bloating in Isfahan in 2020-2021. At the beginning of the study, information on the frequency of abdominal bloating, its severity, the occurrence of early satiety, frequency of borborygmus, frequency of belching, and the frequency of defecation per week was collected. Patients were divided into 3 groups receiving familact probiotic pills that contained 7 bacterial strains, colloidal bismuth subcitrate tablets, and placebo pills for 4 weeks. Afterwards, the frequency and severity of abdominal bloating and other symptoms were compared.
UNASSIGNED: After 2 weeks, patients in the probiotic group had a significantly lower frequency of abdominal bloating compared to other groups (P= 0.006). After 4 and 8 weeks, patients in the probiotic group and bismuth group had a lower frequency of bloating )3.18±3.02, 4.11±3.34) compared to placebo (5.10±3.54) (P= 0.001 and P= 0.037, respectively). During the study, patients in the probiotic group had a significantly lower bloating severity (41.90% had no symptom) compared to bismuth and placebo groups (12.50 ,12.00% had no symptom) (p< 0.05). The frequency of borborygmus was significantly lower in the probiotic group after 2 and 4 weeks during the study compared to other groups (1.62±0.2 Vs 2.69±0.3, 2.45±0.3 ) (P= 0.010 and P= 0.013, respectively).
UNASSIGNED: According to our data, consumption of probiotics improves the frequency and severity of abdominal bloating and reduces borborygmus. Colloidal bismuth subcitrate also has significant effects.
UNASSIGNED: This was a double-blinded randomized clinical trial performed on 125 patients with functional abdominal bloating in Isfahan in 2020-2021. At the beginning of the study, information on the frequency of abdominal bloating, its severity, the occurrence of early satiety, frequency of borborygmus, frequency of belching, and the frequency of defecation per week was collected. Patients were divided into 3 groups receiving familact probiotic pills that contained 7 bacterial strains, colloidal bismuth subcitrate tablets, and placebo pills for 4 weeks. Afterwards, the frequency and severity of abdominal bloating and other symptoms were compared.
UNASSIGNED: After 2 weeks, patients in the probiotic group had a significantly lower frequency of abdominal bloating compared to other groups (P= 0.006). After 4 and 8 weeks, patients in the probiotic group and bismuth group had a lower frequency of bloating )3.18±3.02, 4.11±3.34) compared to placebo (5.10±3.54) (P= 0.001 and P= 0.037, respectively). During the study, patients in the probiotic group had a significantly lower bloating severity (41.90% had no symptom) compared to bismuth and placebo groups (12.50 ,12.00% had no symptom) (p< 0.05). The frequency of borborygmus was significantly lower in the probiotic group after 2 and 4 weeks during the study compared to other groups (1.62±0.2 Vs 2.69±0.3, 2.45±0.3 ) (P= 0.010 and P= 0.013, respectively).
UNASSIGNED: According to our data, consumption of probiotics improves the frequency and severity of abdominal bloating and reduces borborygmus. Colloidal bismuth subcitrate also has significant effects.
摘要：
■功能性腹胀是功能性胃肠病(FGID)之一。这里,我们旨在研究和比较益生菌和胶体次柠檬酸铋对腹胀的影响。
■这是一项双盲随机临床试验，于2020-2021年在伊斯法罕对125例功能性腹胀患者进行。在研究开始时，关于腹胀频率的信息，其严重性,早期饱腹感的发生，borborygmus的频率，打气的频率，收集每周排便频率。患者被分为3组，接受含有7种细菌菌株的familact益生菌丸，胶体次柠檬酸铋片，和安慰剂药4周。之后,比较腹胀和其他症状的频率和严重程度。
■2周后，益生菌组患者的腹胀频率显著低于其他组(P=0.006).4周和8周后，与安慰剂(5.10±3.54)相比,益生菌组和铋组较低的腹胀频率)3.18±3.02,4.11±3.34(分别为P=0.001和P=0.037).在研究期间,与铋和安慰剂组相比，益生菌组的患者腹胀严重程度显着降低（41.90％无症状）（12.50，12.00%无症状)(p<0.05)。在研究期间的2周和4周后，益生菌组的borbygmus频率显着低于其他组（1.62±0.2vs2.69±0.3，2.45±0.3）（分别为P=0.010和P=0.013）。
■根据我们的数据，食用益生菌可改善腹胀的频率和严重程度，并减少腹胀。胶体次柠檬酸铋也具有显著的效果。
■这是一项双盲随机临床试验，于2020-2021年在伊斯法罕对125例功能性腹胀患者进行。在研究开始时，关于腹胀频率的信息，其严重性,早期饱腹感的发生，borborygmus的频率，打气的频率，收集每周排便频率。患者被分为3组，接受含有7种细菌菌株的familact益生菌丸，胶体次柠檬酸铋片，和安慰剂药4周。之后,比较腹胀和其他症状的频率和严重程度。
■2周后，益生菌组患者的腹胀频率显著低于其他组(P=0.006).4周和8周后，与安慰剂(5.10±3.54)相比,益生菌组和铋组较低的腹胀频率)3.18±3.02,4.11±3.34(分别为P=0.001和P=0.037).在研究期间,与铋和安慰剂组相比，益生菌组的患者腹胀严重程度显着降低（41.90％无症状）（12.50，12.00%无症状)(p<0.05)。在研究期间的2周和4周后，益生菌组的borbygmus频率显着低于其他组（1.62±0.2vs2.69±0.3，2.45±0.3）（分别为P=0.010和P=0.013）。
■根据我们的数据，食用益生菌可改善腹胀的频率和严重程度，并减少腹胀。胶体次柠檬酸铋也具有显著的效果。
