PDF(Pubmed)
Abstract：
The genus Flavivirus contains a wide variety of viruses that cause severe disease in humans, including dengue virus, yellow fever virus, Zika virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus. Nonstructural protein 1 (NS1) is a glycoprotein that encodes a 352-amino-acid polypeptide and has a molecular weight of 46-55 kDa depending on its glycosylation status. NS1 is highly conserved among multiple flaviviruses and occurs in distinct forms, including a dimeric form within the endoplasmic reticulum, a cell-associated form on the plasma membrane, or a secreted hexameric form (sNS1) trafficked to the extracellular matrix. Intracellular dimeric NS1 interacts with other NSs to participate in viral replication and virion maturation, while extracellular sNS1 plays a critical role in immune evasion, flavivirus pathogenesis and interactions with natural vectors. In this review, we provide an overview of recent research progress on flavivirus NS1, including research on the structural details, the secretory pathways in mammalian and mosquito cells and the multiple functions in viral replication, immune evasion, pathogenesis and interaction with natural hosts, drawing together the previous data to determine the properties of this protein.
摘要：
黄病毒属含有多种在人类中引起严重疾病的病毒，包括登革热病毒,黄热病病毒,寨卡病毒,西尼罗河病毒,日本脑炎病毒和蜱传脑炎病毒。非结构蛋白1（NS1）是一种糖蛋白，编码352个氨基酸的多肽，分子量为46-55kDa，具体取决于其糖基化状态。NS1在多种黄病毒中高度保守，并以不同的形式发生。包括内质网内的二聚体形式，质膜上的细胞相关形式，或分泌的六聚体形式（sNS1）运输到细胞外基质。细胞内二聚体NS1与其他NS相互作用，参与病毒复制和病毒体成熟，而细胞外sNS1在免疫逃避中起关键作用，黄病毒致病机理和与天然载体的相互作用。在这次审查中,我们概述了黄病毒NS1的最新研究进展，包括结构细节的研究，哺乳动物和蚊子细胞的分泌途径以及病毒复制的多种功能，免疫逃避,发病机理和与自然宿主的相互作用，将以前的数据汇总在一起以确定这种蛋白质的特性。
