PDF(Pubmed)
Abstract：
Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations. Although the use of metabolic modulators has been proposed for several decades, their use in clinical practice has not been established. Natural products, the so-called botanical drugs, are capable of regulating tumor metabolism, particularly in hematopoietic tumors, which could partly explain the biological activity attributed to them for a long time. This review addresses the most recent findings relating to metabolic reprogramming-Mainly in the glycolytic pathway and mitochondrial activity-Of leukemic cells and its role in the generation of resistance to conventional treatments, the modulation of the tumor microenvironment, and the evasion of immune response. In turn, it describes how the modulation of metabolism by plant-derived extracts can counteract resistance to chemotherapy in this tumor model and contribute to the activation of the antitumor immune system.
摘要：
白血病细胞获得复杂且通常是多因素的耐药机制，包括各种代谢改变。虽然代谢调节剂的使用已经提出了几十年，它们在临床实践中的使用尚未确定。天然产品,所谓的植物药,能够调节肿瘤代谢，特别是在造血系统肿瘤中，这可以部分解释长期以来归因于它们的生物活性。这篇综述阐述了与代谢重编程相关的最新发现-主要在糖酵解途径和线粒体活性-白血病细胞及其在产生对常规治疗的抗性中的作用，肿瘤微环境的调节，和逃避免疫反应。反过来,它描述了在这种肿瘤模型中，植物提取物对代谢的调节如何抵消对化疗的抵抗力，并有助于激活抗肿瘤免疫系统。
