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Abstract：
OBJECTIVE: The aim of this study was to identify the mean age at which breast cancer (BC) was first diagnosed in 2010 or 2022, and to evaluate whether there were any changes in age groups at first BC diagnosis.
METHODS: This retrospective cross-sectional study included adult women (18 years or older) who were diagnosed with BC (ICD-10: C50) for the first time in 2010 or 2022 in office-based practices in Germany (in 300 general practices or 95 gynecological practices). We examined the mean age at diagnosis and the percentage of patients in three age groups (18-49, 50-65, and > 65) for both 2010 and 2022. The average age difference between 2010 and 2022 was analyzed using Wilcoxon rank tests, and the proportions of the three age groups were analyzed using chi-squared tests. These analyses were performed separately for patients in general and gynecological practices.
RESULTS: The mean age at which BC was initially diagnosed in 2022 was found to be significantly greater than that in 2010 for both general practices (66.9 years vs. 64.0 years p < 0.001) and gynecological practices (62.2 years vs. 60.3 years, p < 0.001). Early-onset BC decreased from 15.6 to 12.0% in general practices and from 23.2 to 18.2% in gynecological practices between 2010 and 2022. The proportion of new BC diagnoses in the age group 50-65 increased from 36.6 to 40.9% in gynecological practices, but did not increase in general practices.
CONCLUSIONS: The study found that BC was diagnosed at an older age in 2022 than in 2010. In addition, the proportion of early-onset BC cases decreased, while the proportion of cases in the age group 50-65 increased in gynecological practices in Germany.
METHODS: This retrospective cross-sectional study included adult women (18 years or older) who were diagnosed with BC (ICD-10: C50) for the first time in 2010 or 2022 in office-based practices in Germany (in 300 general practices or 95 gynecological practices). We examined the mean age at diagnosis and the percentage of patients in three age groups (18-49, 50-65, and > 65) for both 2010 and 2022. The average age difference between 2010 and 2022 was analyzed using Wilcoxon rank tests, and the proportions of the three age groups were analyzed using chi-squared tests. These analyses were performed separately for patients in general and gynecological practices.
RESULTS: The mean age at which BC was initially diagnosed in 2022 was found to be significantly greater than that in 2010 for both general practices (66.9 years vs. 64.0 years p < 0.001) and gynecological practices (62.2 years vs. 60.3 years, p < 0.001). Early-onset BC decreased from 15.6 to 12.0% in general practices and from 23.2 to 18.2% in gynecological practices between 2010 and 2022. The proportion of new BC diagnoses in the age group 50-65 increased from 36.6 to 40.9% in gynecological practices, but did not increase in general practices.
CONCLUSIONS: The study found that BC was diagnosed at an older age in 2022 than in 2010. In addition, the proportion of early-onset BC cases decreased, while the proportion of cases in the age group 50-65 increased in gynecological practices in Germany.
摘要：
目的：本研究的目的是确定2010年或2022年首次诊断乳腺癌（BC）的平均年龄，并评估首次诊断BC时年龄组是否有任何变化。
方法：这项回顾性横断面研究纳入了2010年或2022年首次在德国的办公室实践（300个一般实践或95个妇科实践）中诊断为BC（ICD-10：C50）的成年女性（18岁或以上）。我们检查了2010年和2022年诊断时的平均年龄和三个年龄组（18-49、50-65和>65）的患者百分比。2010年至2022年的平均年龄差异采用Wilcoxon秩检验进行分析，并使用卡方检验分析三个年龄组的比例。这些分析分别针对普通和妇科实践中的患者进行。
结果：这两种一般做法在2022年最初诊断为BC的平均年龄明显大于2010年的平均年龄（66.9岁vs.64.0年p<0.001）和妇科实践（62.2年vs.60.3年,p<0.001)。在2010年至2022年期间，一般实践中的早发性BC从15.6％降至12.0％，在妇科实践中从23.2％降至18.2％。50-65岁年龄组中新诊断BC的比例在妇科实践中从36.6％增加到40.9％，但在一般实践中并没有增加。
结论：研究发现，与2010年相比，2022年诊断出BC的年龄更大。此外,早发性BC病例的比例下降，而在德国的妇科实践中，50-65岁年龄段的病例比例增加。
方法：这项回顾性横断面研究纳入了2010年或2022年首次在德国的办公室实践（300个一般实践或95个妇科实践）中诊断为BC（ICD-10：C50）的成年女性（18岁或以上）。我们检查了2010年和2022年诊断时的平均年龄和三个年龄组（18-49、50-65和>65）的患者百分比。2010年至2022年的平均年龄差异采用Wilcoxon秩检验进行分析，并使用卡方检验分析三个年龄组的比例。这些分析分别针对普通和妇科实践中的患者进行。
结果：这两种一般做法在2022年最初诊断为BC的平均年龄明显大于2010年的平均年龄（66.9岁vs.64.0年p<0.001）和妇科实践（62.2年vs.60.3年,p<0.001)。在2010年至2022年期间，一般实践中的早发性BC从15.6％降至12.0％，在妇科实践中从23.2％降至18.2％。50-65岁年龄组中新诊断BC的比例在妇科实践中从36.6％增加到40.9％，但在一般实践中并没有增加。
结论：研究发现，与2010年相比，2022年诊断出BC的年龄更大。此外,早发性BC病例的比例下降，而在德国的妇科实践中，50-65岁年龄段的病例比例增加。
